私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

當前位置: 首頁 >> 產業發展 >> 正文

Biodegradable amphiphilic graft polymers for durg delivery

時間:2004-12-02
關鍵詞:Biodegradable amphiphilic graft polymers durg delivery 來源:International Symposium on Biological Polyesters ,Auguest 22-27, 2004

 

H. Wang, T. Peng, L. Yu, T. Wan, and S.-X. Cheng*

 

Laboratory of Biomedical Polymers of Ministry of China, Department of Chemistry,

Wuhan University, 430072, China

 

Keywords: biodegradable polymers, drug controlled release, amphiphilic

 

Amphiphilic biodegradable polymers are of special interest as biomaterials because of their unique physicochemical properties and the wide variety of applications in biomedical fields. In this study, we successfully synthesized a series of biodegradable amphiphilic graft polymers by grafting poly(2,2-dimethyltrimethylene carbonate) (PDTC) sequences onto poly-α,β-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA) backbone (Figure 1). PDTC is a hydrophobic biodegradable polycarbonate1 and PHEA is a water-soluble, nontoxic, nonantigenic biodegradable polymer.2 In our investigation, by initiating the ring-opening polymerization of DTC by -OH groups in PHEA, amphiphilic graft polymers were obtained by one-step reaction conveniently. The brush-like structure of PHEA-g-PDTC can be adjusted by controlling the ratio of the monomer DTC to the macroinitiator PHEA as shown in Table 1. Because of the adjustable amphiphilicity and degradation rate of these polymers, they have promising applications in drug delivery (Figure 2).

 

 

[1]     Matsuo J., et al., 1998. Macromolecules 31, 4432-4438.

[2]     Giammona G., et al., 1987. J. Polym. Sci. Polym. Chem. 25, 2813-2818.

 

      論文來源:International Symposium on Biological Polyesters ,Auguest 22-27, 2004

主站蜘蛛池模板: 宁津县| 阜阳市| 介休市| 霍州市| 康定县| 抚顺县| 南木林县| 山阴县| 古田县| 晋州市| 监利县| 万盛区| 惠水县| 沙田区| 徐水县| 桦川县| 饶平县| 宁津县| 灌南县| 神农架林区| 驻马店市| 沁源县| 涞水县| 洛川县| 琼结县| 昌都县| 湖南省| 汕头市| 乐清市| 旬阳县| 苍梧县| 天长市| 灵台县| 监利县| 谢通门县| 清丰县| 阳原县| 新密市| 澄江县| 正镶白旗| 边坝县|