鎴戜滑鐢ㄦ樉寰暅鏉ヨ瀵熺粏鑳烇紝鍥犱負鏄懼井闀滃彲浠ヨ鐗╀綋鐨勫獎鍍忓彉澶с備絾濡傛灉鎶婄墿浣撴湰韜彉澶т笉灝辨湁鐩稿悓鏁堟灉錛熻繖縐嶇湅浼間笉縐戝鐨勮娉曡濡備綍鍔炲埌錛熺瓟妗堣窡濠村効鐢ㄧ殑灝垮竷鏈夊叧銆傞夯鐪佺悊宸ュ闄㈢緇忓伐紼嬪笀 Edward Boyden 鐮斿彂涓縐嶇О涓衡滄墿灞曟樉寰暅鈥?expansion microscopy) 鐨勬妧鏈紝璁╄瑙傚療鐨勭墿浣撹啫鑳錛岀敓鐗╁瀹剁敋鑷沖彲浠ョ敤鏅氭樉寰暅鐪嬪埌鍒嗗瓙絳夌駭鐨勮剳閮ㄧ粏鑺傘?
涓庢槀璐墊妧鏈湁鐩稿悓鏁堟灉
Boyden 鐨勬妧鏈叾瀹炶窡 2014 騫磋璐濆皵鍖栧濂栦笁浣嶅緱涓葷殑钀ゅ厜鏄懼井鎶鏈彲浠ュ仛涓姣斻傝璐濆皵濂栫殑鏄懼井闀滄妧鏈獊鐮翠簡鍙鍏夋渶灝忔嘗闀?400 綰崇背鐨勯檺鍒訛紝瀵逛簬璺濈鍙湁 20 綰崇背鐨勭墿浣撲粛鑳芥竻鏅板垎杈紝涓嶈繃緙虹偣鏄墍闇鐨勪華鍣ㄥ緢鏄傝吹錛屼笖闈㈠鏈夊帤搴︾殑鐗╀綋杈冧笉鏄撹瀵燂紝渚嬪鑲跨槫緇嗚優鎴栨槸鏁翠釜澶ц剳銆侭oyden 鐨勬妧鏈垯鍙互瑙傚療绔嬩綋鐨勭粍緇囷紝渚嬪鑴戦儴紲炵粡緇嗚優涔嬮棿紿佽Е闂撮殭鍙婇棿闅欎竴绔殑紿佽Е閽?(synaptic bouton)銆?
Boyden 榪愮敤鐨勬槸涓欑儻閰哥被鑱氬悎鐗┿傚父瑙佺殑灝垮竷鎴栧崼鐢熸涔嬫墍浠ュ叿鏈夐攣姘村姛鑳斤紝鍏朵腑渚垮惈鏈変笝鐑吀錛涗笝鐑吀榪樿兘鐣欎綇铔嬬櫧璐ㄥ垎瀛愩傚湪 Boyden 鐨勬妧鏈笅錛岄鍏堣鎶婅悿鍏夊垎瀛愰攣瀹氬湪瑕佽瀵熺殑铔嬬櫧璐ㄤ笂錛岀劧鍚庡紑濮嬫敞姘達紝瑕佽瀵熺殑緇勭粐鍥犱負鍔犲叆涓欑儻閰歌岃啫鑳浜?91.125 鍊嶏紙涓夌淮鏂瑰悜鍚勮嚜鑶ㄨ儉 4.5 鍊嶏級銆傚洜涓虹粍緇囪啫鑳錛岃钀ゅ厜鍒嗗瓙鏍囪鐨勮泲鐧借川褰兼璺濈涔熸媺寮錛屽彲浠ヨ鐢ㄥ彲瑙佸厜榪涜瑙傚療鐨勬樉寰暅涔熻兘鐪嬭銆侭oyden 琛ㄧず榪欓」鎶鏈彲浠ヨ鍘熷厛璺濈鍦?60 綰崇背浠ヤ笂鐨勫垎瀛愯娓呮瑙傚療銆?
鐗╄川鑶ㄨ儉浣嗘棤澶璐ㄥ彉
閲嶈鐨勬槸錛岀粍緇囦腑鐨勭粏鑳炰粛鐒朵繚鎸佸畬濂界姸鎬侊紝铔嬬櫧璐ㄧ殑鐩稿浣嶇疆涓庢柟鍚戞病鏈夊お澶х殑鏀瑰彉錛屽涓婂浘宸︽槸鑶ㄨ儉鍚庣殑鏍峰瓙錛屼笌鍥懼彸鐨勫師濮嬬姸鎬佹瘮杈冩敼鍙樹笉澶с傝繖欏規敼鍙樻牴鎹爺絀跺洟闃熺殑浼拌錛屽ぇ綰︽槸 1% 鑷?4% 涔嬮棿銆?
2014 騫磋璐濆皵鍖栧濂栧緱涓諱箣涓鐨?Stefan Hell 琛ㄧず錛岃繖欏規妧鏈緢鏈夎叮涔熷煎緱緇х畫鍙戝睍錛屼粬鎻愬埌 1990 騫翠唬寰峰浗灝辨湁縐戝瀹舵湁綾諱技鐨勭偣瀛愶紝浣嗙湅鏉?Boyden 鐨勭爺絀跺洟闃熸墠鏄湡姝ｆ妸鏋勬兂瀹炵幇鐨勪漢銆?
