Synthesis of Poly(N-isopropylacrylamide)-b-Poly(ε-caprolactone) and Its Inclusion Compound of β -Cyclodextrin
writer：Zhongyu Duan, Li ZHang, Huili Wang, Bing Han, Binyuan Liu, Il Kim
keywords：Bifunctional initiator, Block copolymer
source：期刊
specific source：React Funct Polym
Issue time：2014年
Well-defined amphiphilic poly(N-isopropylacrylamide)-b-Poly(ε-caprolactone) (PNIPAM-b-PCL) block copolymers have been successfully prepared in two steps. PNIPAM?OH is firstly prepared by using 4,4’-azobis(4-cyano-1-pentanol) as bifunctional initiator, and then PNIPAM-b-PCL copolymer is synthesized via a ring-opening polymerization of CL using PNIPAM?OH as a macro-initiator in the presence of stannous octoate as a catalyst. The PNIPAM-b-PCL copolymers self-assemble to form spherical micelles of 50-130 nm in diameter, which can be modulated by the chain length of PCL block. The inclusion complexes are fabricated by treating PNIPAM-b-PCL with β-cyclodextrin and they are characterized by infrared and 1H NMR spectroscopies, x-ray powder diffraction, thermogravimetric analysis, and differential scanning calorimetry.