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車超越工作發表在ACS Biomater Sci Eng并入選ACS Editors’ Choice
來源:石恒沖研究員個人網站 發布日期:2020-03-05

Abstact: Uncontrolled hemorrhage is the leading factor causing death in military trauma and clinical practice and is usually accompanied with bacterial infection. The fabrication of a functional hemostatic sponge for combating bacteria is of vital importance. Poly(hexamethylene biguanide) hydrochloride (PHMB) has been shown to have a remarkable bactericide effect. However, PHMB after use might have a toxic effect on humans. Herein, a powerful surface-adaptive, on-demand antibacterial hemostatic sodium alginate/gelatin sponge is fabricated by sequential spray-assisted layer-by-layer assembly of PHMB and hyaluronic acid (HA). The HA upper layer could endow the coating surface with better biocompatibility under physiological conditions. Once bacteria invade, the secreted hyaluronidase could degrade the upper HA layer, and then the exposed PHMB layer could kill the bacteria. The coated sponge shows excellent biocompatibility, as negatively charged HA can prevent the exposure of bactericidal PHMB. Moreover, the coated sponge exhibited excellent hemostatic properties in vitro and in vivo by aggregating and activating blood cells. Our strategy provides a novel approach to the design of surface-adaptive and on-demand bactericidal coatings on the surface of hemostatic sponges, which has the advantage of avoiding infection complications during hemostasis.

ACS Editors’ Choice是美國化學學會(ACS)于2014年1月1日推出的一項擴大刊物影響力的舉措。該服務每天從ACS開辦的51種同行評議期刊中選取一篇具有重大科學意義的優秀論文,入選率低于1%,并成為向公眾永久免費開放的瀏覽資源,且無需論文作者付費。ACS Editors’ Choice的文章發放到ACS的首頁上,以圖片形式滾動播放7天,相當于每天的頭條。ACS旗下每個期刊的編輯團隊要為“ACS Editors’ Choice”窗口推薦論文,推薦選定的論文必須是每個雜志所有論文中的極品佳作。

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