私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

相關鏈接
聯系方式
  • 通信地址:陜西科技大學化學化工學院
  • 郵編:710021
  • 電話:15991680664
  • 傳真:
  • Email:baiyang@sust.edu.cn
當前位置:> 首頁 > 論文著作 > 正文
β-Cyclodextrin-modified hyaluronic acid-based supramolecular self-assemblies for pH- and esterase- dual-responsive drug delivery
作者:Yang Bai,*a Cai-Ping Liu,a Di Chen,ad Cheng-Fei Liu,c Long-Hai Zhuo,a Hui Li,*b Chao Wang, a Huai-Ti
關鍵字:β-cyclodextrin, Drug delivery, Host-guest interaction
論文來源:期刊
具體來源:Carbohydrate Polymers.
發表時間:2020年

Although some drug-basedsupramolecular systems have been constructed to overcome multidrug resistance and enhance the bioavailability of chemical drugs, strengthening the specific stimuli-responsive and active targeting ability of these systems is still a major challenge. In this paper, the synthesis and self-assembly behaviour of supramolecular self-assemblies with active targeting β-cyclodextrin-modified hyaluronic acid (HA-CD) and drug-drug conjugates (curcumin-oxoplatin, Cur-Pt) as building moieties were carefully investigated. Notably, the curcumin was chosen not only as the chemical anti-cancer drug, but also acted as the guest molecule which could be included into CD cavity to form host-guest interaction-based supramolecular assemblies. The obtained self-assemblies exhibited pH- and esterase-responsive drug release behaviours. Furthermore, basic cell experiments were performed to prove their effective cellular toxicity based on A549 cells and PC3 cells with high expression of CD44 receptor but they showed no toxicity to normal LO-2 cells with low expression of CD44 receptor, which suggests their potential application in the targeted drug release field.

主站蜘蛛池模板: 噶尔县| 武冈市| 垫江县| 建平县| 台山市| 湘阴县| 利川市| 南宁市| 连平县| 封丘县| 常熟市| 潍坊市| 怀安县| 缙云县| 南投县| 安塞县| 阿瓦提县| 洮南市| 吐鲁番市| 苍梧县| 乐至县| 永康市| 彰化县| 新田县| 呼玛县| 个旧市| 孙吴县| 彝良县| 彰武县| 承德市| 砚山县| 常山县| 荔波县| 兴化市| 九龙城区| 中方县| 荃湾区| 德庆县| 西城区| 文昌市| 南投县|