Characterization and Degradability of the e-Caprolactone/lactide Graft Copolymers
作者：Weifeng Dai, Jiayun Zhu, Aoyu Shangguan, Meidong Lang*
關鍵字：Poly(ε-caprolactone)， Polylactide， Graft copolymers， Ring-opening polymerization，2-Oxepane-1,5-dione
論文來源：期刊
具體來源：European Polymer Journal. 2009, 45, 1659-1667
發(fā)表時間：2009年
The novel comb-type biodegradable graft copolymers based on ε-caprolactone and l-lactide were synthesized. Firstly, 2-oxepane-1,5-dione (OPD) was synthesized by the Baeyer–Villiger oxidation of 1,4-cyclohexanedione, and was subsequently copolymerized with ε-caprolactone (CL) to produce poly(2-oxepane-1,5-dione-co-ε-caprolactone) (POCL) catalyzed by stannous(II) 2-ethylhexanoate in toluene. Then, POCL was converted into poly(4-hydroxyl-ε-caprolactone-co-ε-caprolactone) (PHCL) using sodium borohydride as reductant. Finally, poly(4-hydroxyl-ε-caprolactone-co-ε-caprolactone)-g-poly(l-lactide) (PHCL-g-PLLA) were prepared successfully by bulk ring-opening polymerization of l-lactide using PHCL as a macro-initiator. All the copolymers have been characterized by 1H and 13C NMR, DSC, and GPC. Compared with the random copolymer of poly(CL-co-LA), the elongation is highly increased. And the thermal analysis showed that the crystallization rate of the PCL backbone in the graft copolymers was greatly reduced compared to the PCL homopolymer. The hydrolytic degradation of the copolymer was much faster in a phosphate buffer (pH = 7.4) at 37 °C, which is confirmed by the weight loss and change of intrinsic viscosity.