AngewChem--BiomimeticTransmembrane Channels with High Stability and Transporting Efficiency from Helically Folded Macromolecules
writer：Chao Lang,Wenfang Li,Zeyuan Dong, et al.
keywords：Transmembrane channels, Helical polymers
source：期刊
specific source：Angew Chem Int Ed
Issue time：2016年
Membrane channels span the cellular lipid bilayers to transport ions and molecules into cells with sophisticated properties including high efficiency and selectivity. It is of particular biological importance in developing biomimetic transmembrane channels with unique functions by means of chemically synthetic strategies. An artificial unimolecular transmembrane channel using pore-containing helical macromolecules is reported. The self-folding, shape-persistent, pore-containing helical macromolecules are able to span the lipid bilayer, and thus result in extraordinary channel stability and high transporting efficiency for protons and cations. The lifetime of this artificial unimolecular channel in the lipid bilayer membrane is impressively long, rivaling those of natural protein channels. Natural channel mimics designed by helically folded polymeric scaffolds will displayrobust and versatile transport-related properties at single-molecule level.