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Aptamer Functionalized DNA Hydrogel for Wise-Stage Controlled Protein Release
作者:Chen Liu, Jialun Han, Yuxuan Pei, Jie Du
關鍵字:DNA hydrogel; aptamers; self-assembled; controlled release
論文來源:期刊
具體來源:Appl. Sci. 2018, 8, 1941
發表時間:2018年

With the simple functionalization method and good biocompatibility, an aptamer-integrated

DNA hydrogel is used as the protein delivery system with an adjustable release rate and time by using complementary sequences (CSs) as the biomolecular trigger. The aptamer-functionalized DNA hydrogel was prepared via a one-pot self-assembly process from two kinds of DNA building blocks (X-shaped and L-shaped DNA units) and a single-stranded aptamer. The gelling process was achieved under physiological conditions within one minute. In the absence of the triggering CSs, the aptamer grafted in the hydrogel exhibited a stable state for protein-specific capture. While hybridizing with the triggering CSs, the aptamer is turned into a double-stranded structure, resulting in the fast dissociation of protein with a wise-stage controlled release program. Further, the DNA hydrogel with excellent cytocompatibility has been successfully applied to human serum, forming a complex matrix. The whole process of protein capture and release were biocompatible and could not refer to any adverse factor of the protein or cells. Thus, the aptamer-functionalized DNA hydrogel will be a good candidate for controlled protein delivery.

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