私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

相關(guān)鏈接
聯(lián)系方式
  • 通信地址:山東省青島市市北區(qū)登州路38號
  • 郵編:266021
  • 電話:86-0532-82991791
  • 傳真:
  • Email:fanchangjiang@hotmail.com
當(dāng)前位置:> 首頁 > 論文著作 > 正文
Effects of Permeability and Living Space on Cell Fate and Neo-Tissue Development in Hydrogel-Based Scaffolds: A Study With Cartilaginous Model
作者:Changjiang Fan, Dong-An Wang
關(guān)鍵字:Hydrogel, tissue engineering scaffold
論文來源:期刊
發(fā)表時(shí)間:2015年
One bottleneck in tissue regeneration with hydrogel scaffolds is the limited understanding of the crucial factors for controlling hydrogel’s physical microenvironments to regulate cell fate. Here, the effects of permeability and living space of hydrogels on encapsulated cells’ behavior were evaluated, respectively. Three model hydrogel-based constructs are fabricated by using photo-crosslinkable hyaluronic acid as precursor and chondrocytes as model cell type. The better permeable hydrogels facilitate better cell viability and rapid proliferation, which lead to increased production of extracellular matrix (ECM), e.g. collagen, glycosaminoglycan. By prolonged culture, nano-sized hydrogel networks inhibit neo-tissue development, and the presence of macro-porous living spaces significantly enhance ECM deposition via forming larger cell clusters and eventually induce formation of scaffold-free neo-tissue islets. The results of this work demonstrate that the manipulation and optimization of hydrogel microenvironments, namely permeability and living space, are crucial to direct cell fate and neo-tissue formation.
主站蜘蛛池模板: 天柱县| 巨鹿县| 南宫市| 双流县| 郴州市| 饶河县| 澎湖县| 化州市| 海晏县| 万载县| 杨浦区| 平顶山市| 离岛区| 锦州市| 绿春县| 平南县| 天长市| 边坝县| 衡南县| 西和县| 齐河县| 广河县| 永寿县| 邳州市| 乌拉特后旗| 海晏县| 长海县| 青岛市| 开远市| 兴山县| 营山县| 绥中县| 绿春县| 邵武市| 芦溪县| 淳安县| 公主岭市| 阿合奇县| 石首市| 莱芜市| 米泉市|