Biocompatible amphiphilic hyperbranched nanocapsules with a functional core: Synergistic encapsulation and asynchronous release properties towardsmulti-guest molecules
writer：Wei Tian,*Anlin Lv,*Yunchuan Xie, Xiaoying Wei, Bowu Liu and Xiaoyan Lv
keywords：amphiphilic hyperbranched nanocapsules,Synergistic encapsulationasynchronous release properties,
source：期刊
specific source：RSC Advances, 2012, 2, 11976–11987
Issue time：2012年
To achieve an encapsulation–release property towards multi-guest molecules, amphiphilic hyperbranched nanocapsules (AHN) consisting of a functional hyperbranched poly(β-cyclodextrin) [HBP(β-CD)] core and a methoxy polyethylene glycol shell was first constructed by click chemistry.The encapsulation–release capacity and corresponding mechanism of AHN towards multi-guest molecules were investigated by fluorescence and UV-vis spectroscopy. The results indicated that the encapsulation–release properties of AHN were pH dependent and can be applied to multi-guest systems. The multi-guest encapsulation capacity of AHN was derived from the synergistic encapsulation phenomenon of different guest molecules and the molecular recognition property of the HBP(β-CD) core. Compared with single-guest systems, AHN displays a sustained release
characteristic accompanied by an ‘‘asynchronous release phenomenon’’ in multi-guest release systems. The release rate can also be effectively controlled because of the molecular recognition property of the HBP(β-CD) core. Both in vitro cell apoptosis and in vivo systematic toxicity assays confirmed that AHN possessed good biocompatibility.