作者：J. Leblond,; H. Gao, A. Petitjean, Leroux, J.C. Leroux,
關(guān)鍵字：pH-Responsive, molecular tweezers
論文來源：期刊
具體來源：J Am Chem Soc, 2010, 132 (25), pp 8544–8545
發(fā)表時間：2010年
In this work, we report a pH-sensitive molecular tweezer prototype that could serve as a fast responding unit to manipulate the release rate of a substrate (Figure 1A) by a macromolecular carrier. The structure comprises three elements: (i) a poly(ethylene glycol) (PEG) backbone to provide water solubility to the carrier, (ii) two naphthalene arms to ensure binding to the substrate, and (iii) a switching unit, i.e. a methoxyphenylpyridinemethoxyphenyl triad, ortho-Py, to allow the tweezer to switch from the U- to W-shape conformations at acidic pH, thereby decreasing its affinity
for the substrate.