[Molecular Pharmaceutics] One Stone Kills Three Birds: Novel Boron-containing Vesicles for Potential BNCT, Controlled Drug Release and Diagnostic Imaging
作者：Gaojian Chen, Jingying Yang, Gang Lu, Pichu Liu, Qianjin Chen, Zuowei Xie, Chi Wu*
關鍵字：http://pubs.acs.org/doi/abs/10.1021/mp400641u
論文來源：期刊
具體來源：Molecular Pharmaceutics
發(fā)表時間：2014年
A new conjugate polymer was prepared by an efficient
thiol-ene coupling of one carborane with a linear PEG chain (Mn = 2,000 g/mol)
and each carborane was further labeled with a fluorescence rhodamine dye. Such
a novel polymer can associate in water to form narrowly distributed spherical
vesicles that was characterized using a range of methods, including laser light
scattering, confocal laser scanning microscopy and TEM. The vesicular structure
is potentially multi-functional in biomedical applications; namely, serving as
a boron neutron capture therapy (BNCT) agent, a hydrophilic drug carrier, and a
diagnostic imaging fluorescent probe. As expected, either cleaving the
thiol-ene linked PEO chain by esterase or destroying carborane by neutron
irradiation results in a dismantlement of such a vesicle structure to release
its encapsulated drugs. Its potential biomedical applications have been in
vitro and in vivo evaluated. Our preliminary results reveal that these small
vesicles can be quickly taken up by cells and have an enhanced stability in
blood stream so that their targeting to specific cancer cells becomes feasible.