Facile Preparation of Hyperbranched Glycopolymer via AB3* Inimer Promoted by a Hydroxy/Cerium (IV) Redox Process
writer：Feng Liu, Yonggang Wu,* Libin Bai, X. Peng, Hailei Zhang,* Y. Zhang, P. An, S. W, G. Ma, Xinwu Ba*
keywords：無
source：期刊
specific source：Polymer Chemistry
Issue time：2018年
The facile preparation of hyperbranched glycopolymers was performed without protecting group chemistry, where the methyl-6-O-methacryloyl-α-D-glucoside (6-O-MMAGlc) monomer was adopted as AB3*-type inimer. The polymerization was initiated by hydroxy/cerium(IV) redox process, and could be named as the self-condensing vinyl copolymerization/redox (SCVP /Redox). The oxygen radical (C-O·), rather than carbon radical (·C-OH), was generated by the redox reaction of Ce(IV) with –OH groups on the pyranose in 6-O-MMAGlc, which was confirmed by the NMR data. The formation of branching point and linear chain growth were defined to give degree of branching (DB). Linear increase of the DB was observed as the concentration of Ce(IV) increased, implying the facile control of DB. More interestingly, the hyperbranched glycopolymers on amyloid fibrillation of hen egg-white lysozyme (HEWL) exhibited a greater inhibition activity than that of linear analogue. This substantial study would provide more room to enrich the family of glycopolymers and extend their potential application in biomedicine and biomaterials.