Halloysite Nanotube-Based H2O2-Responsive Drug Delivery System with a Turn on Effect on Fluorescence for Real-Time Monitoring
writer：[2] Cong Cheng, Yan Gao*, Weihua Song, Qiang Zhao, Haisong Zhang, Hailei Zhang*
keywords：halloysite
source：期刊
specific source：Chemical Engineering Journal
Issue time：2020年
In this paper, a
novel halloysite-based hydrogel with a “turn-on” fluorescence character upon H2O2
was facilely prepared and used to construct the H2O2-responsive
drug delivery system, in which a coprecipitation
method was proposed to afford the drug-loaded halloysite
nanotubes
(DHNTs). DHNTs were carefully characterized by
FTIR, TGA, XPS, XRD and TEM to demonstrate that the drugs were mainly loaded
into the cavity rather than attached on the external surface of halloysite nanotubes (HNTs). The B-C linkage in the
as-prepared hydrogel was broken in the presence of H2O2,
resulting in the degradation and thereby a responsive
release. The drug release was almost not occurred under the
physiological concentration ([H2O2] = 0.02 μM), while a
complete release (>90%) can be achieved under pathological concentration
([H2O2] = 200 μM). Moreover, the broken of B-C linkage
triggered a transformation from arylboronates to phenols,
in which the formed fluorescein gave rise to the change from non-fluorescent
to fluorescent of the hydrogels.
The fluorescence intensity enhanced
with the increase of release rate, in which a good linear relationship can be
achieved. The attractive properties make the halloysite-based
hydrogels a promising
application in the field of biomedicine.