writer：何乃普*, 王榮民
keywords：蛋白質, 水溶性高分子, 嵌段共聚物, 多糖, 非共價, 自組裝
source：期刊
specific source：http://www.progchem.ac.cn/CN/abstract/abstract10773.shtml
Issue time：2012年
蛋白質是一類具有獨特三維空間結構的生物高分子,其分子內部非共價鍵協同作用是形成三維空間結構的重要驅動力。同時,蛋白質分子與其他高分子之間也可以通過非共價鍵作用實現自組裝。高分子鏈和蛋白質的結構特征是實現自組裝的關鍵,溶液pH值、離子強度以及溫度的變化會影響它們之間非共價鍵作用的類型和強度。本文歸納了水溶性高分子、嵌段共聚物和多糖與球狀蛋白自組裝的最新研究進展,分別從分子結構特征和溶液性質等因素討論了其對高分子與蛋白質實現自組裝的影響。其中,多糖與蛋白質的非共價鍵作用是化學與生物科學交叉領域最為活躍的研究課題之一,通過研究蛋白質與其他高分子的非共價鍵作用,對于理解和認識生命過程的本質與規律具有重要的意義,同時,在材料科學、納米技術、食品科學等相關領域具有重要的應用價值。
Protein is a class of major biomacromolecules with a unique three-dimensional spatial structures. The intramolecular cooperative non-covalent interactions of protein play a crucial role in formation of this structure. Meanwhile, self-assembly of protein with other polymers can be also induced by these interactions. The structures of polymer chain and protein play a key role in the self-assembly of protein with polymer. The changes of pH, ionic strength and temperature of solution affect the type and intensity of non-covalent interactions. The present review summaries the latest research on self-assembly of the water-soluble polymers, block copolymers, and polysaccharides with globular protein. The molecular structure of polymers and solution properties effecting on the self-assembly of protein with polymers are discussed in details. Especially, non-covalent interaction between polysaccharide and protein is a major research topic in interdisciplinary field between chemistry and biology. Understanding of non-covalent interactions between protein and other polymers is benefit to discover the nature and rule of life, and has important applications in materials science,