A Smart H2O2-Responsive Drug Delivery System Made by Halloysite Nanotubes and Carbohydrate Polymers
writer：Feng Liu, Libin Bai, Hailei Zhang, Hongzan Song, Liandong Hu, Yonggang Wu, and Xinwu Ba
keywords：halloysite nanotubes, hydrogel, H2O2-responsiveness
source：期刊
specific source：ACS Appl. Mater. Interfaces
Issue time：2017年
A novel chemical hydrogel was facilely achieved by coupling
1,4-phenylenebisdiboronic acid-modified halloysite nanotubes (HNTs-BO) with
compressible starch. The modified HNTs and prepared hydrogel were characterized
by solid-state nuclear magnetic resonance (NMR), Fourier transform infrared
spectroscopy (FTIR), scanning electron microscopy (SEM) and transmission electron
microscope (TEM). The linkage of B-C in the hydrogel can be degraded into B-OH
and C-OH units in the presence of H2O2, and result into the degradation of the
chemical hydrogel. Pentoxifylline was loaded into the lumen of HNTs-BO and then
give the pentoxifylline-loaded hydrogel. Drug release profile shows that it was no
more than 7% dissolved when using PBS solution as release medium. Notably, a
completely released (near 90%) can be achieved with the addition of H2O2 ([H2O2]
=1×10-4 M), suggesting a high H2O2-responsiveness of as-formed hydrogel. The drug
release results also show that the “initial burst release” can be effectively suppressed
by loading pentoxifylline inside the lumen of HNTs than embedding the drug in
hydrogel network. The drug-loaded hydrogel with H2O2-responsive release behaviour
may open up a broader application in the field of biomedicine.