私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

Links
Contact Info.
  • Address:北京市海淀區中關村南大街5號院,北京理工大學材料學院
  • Zip:100081
  • Tel:010-68912658
  • Fax:
  • Email:
Current Location :> Home > Publications > Text
Total Synthesis of Marinomycin A Using Salicylate as a Molecular Switch to Mediate Dimerization
writer:P. Andrew Evans*, Mu-Hua Huang, Michael J. Lawler, Sergio Maroto
keywords:total sythesis, marine natural products, marinomycin, MRSAR
source:期刊
specific source:Nature Chemistry
Issue time:2012年

  Antibiotics play a signi?cant role in human health because of their ability to treat life-threatening bacterial infections. The growing problems with antibiotic resistance have made the development of new antibiotics a World Health Organization priority. Marinomycin A is a member of a new class of bis-salicylate-containing polyene macrodiolides, which have potent antibiotic activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium.
  Herein, we describe a triply convergent synthesis of this agent using the salicylate as a novel molecular switch for the chemoselective construction of the macrodiolide. This strategy raises new questions regarding the biosynthetic role of the salicylate and its potential impact on the mechanism of action of these types of agents. For instance, in contrast to penicillin, which enhances the electrophilicity of the cyclic amide through ring strain, salicylates reduce the electrophilicity of the aryl ester through an intramolecular resonance-assisted hydrogen bond to provide an amide surrogate.