Surface Modification of Hydrophobic PMMA Intraocular Lens by the Immobilization of Hydroxyethyl Methacrylate for Improving Application in Ophthalmology
writer：Yanlin Wei;Yashao Chen;Peng Liu; Qiang Gao;Yu Sun;Changzheng Huang
keywords：Intraocular lens,Surface modification,DBD plasma
source：期刊
specific source：Plasma Chem Plasma Process (2011) 31:811–825
Issue time：2011年
To improve application of hydrophobic polymethyl methacrylate intraocular
lens (PMMA IOL) in a convenient and continuous way, 2-hydroxyethyl methacrylate
(HEMA) was immobilized by dielectric barrier discharge plasma at relatively high pressure. The hydrophilicity and topography of the modified IOL surface were comprehensively evaluated by contact angle and atomic force microscopy, while the surface biocompatibility of the modified IOL was investigated by platelets adhesion and cells proliferation experiments. The results revealed that the hydrophilicity of the HEMA-g-PMMA IOL samples were significantly and permanently improved. Less platelets attachment was observed on the modified IOL, especially in the HEMA2-g-PMMA IOL group (with 1.65 9 10-1 mol/L HEMA concentration), which also suppressed the proliferation of cells.