Tetramethyguanidine as an inexpensive and efficient ligand for the palladium catalyzed Heck reaction
writer：Shenghai Li, Haibo Xie, Suobo Zhang*, Yingjie Lin, Jianing Xu, Jungang Cao
keywords：Tetramethylguanidine, Heck reaction, Palladinium, Ligand
source：期刊
specific source：Synlett.
Issue time：2005年
An inexpensive and efficient Pd(OAc)2/tetramethylguanidine
(TMG) or PdCl2/TMG catalytic system has been developed for the Heck
reaction of an olefin with an aryl halide. The TONs were up to 1000000 when
iodobenzene was used as the substrate with butyl acrylate as the reactant. In
addition, [Pd(TMG)4]Cl2(H2O)8, an
air-stable compound, effectively promoted the Heck reaction, which demonstrated
that TMG acted as a ligand in this reaction system.