【Biomaterials Science】Biomimetic Self-coacervation Adhesive with Tough Underwater Adhesion for Ultrafast Hemostasis and Infected Wound Healing（IF=6.6）
作者：Tingwu Liu, Wen Sun, Xu Zhang, Donghua Xu, Mingzhe Wang, Qiuyan Yan,* Jinghua Yin, Shifang Luan.
關(guān)鍵字：Polyelectrolyte adhesive, Self-coacervating, Hemostasis, Antibacterial, Wound healing
論文來源：期刊
具體來源：Biomaterials Science
發(fā)表時(shí)間：2023年
Abstract：
Massive bleeding and wound infection due to severe trauma pose a huge threat to the life and health of sufferers, so it is of clinical importance to fabricate adhesive with rapid hemostatic and superior antibacterial capabilities. However, the weak wet adhesion and insufficient function of existing bioadhesives limited their practical application. In this study, a sandcastle worm proteins inspired polyelectrolyte adhesive self-coacervated of poly-γ-glutamic acid (PGA) and lysozyme (LZM) was developed. The adhesive exhibited strong underwater adhesion to various surfaces (>250 KPa for solid plates and >50 KPa for soft tissues) and maintained at 80 KPa even soaked in water for 7 days. Rat liver and tail defect bleeding models revealed that the hemostatic efficiency was superior to commercial samples. The in vitro antimicrobial tests showed that the bacterial inhibition to Staphylococcus aureus and Escherichia coli achieved almost 100%. Additionally, the infected wound regeneration model demonstrated that the healing rate of the adhesive group was about 100% within 7 days, which was greater than that of control group. In vitro and in vivo experiments proved that this facile prepared adhesive will be a promising material to fulfil the integration functions for rapid wound closure and facilitating wound healing