私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

當前位置:群英聚首 > 論文著作 > 正文
Enhanced water-solubility and antibacterial activity of novel chitosan derivatives modified with quaternary phosphonium salt
來源:陳仕國教授個人網站 發布日期:2018-01-02
作者:Dan Zhu, Honghao Cheng, Jianna Li, Wenwen Zhang, Yuanyuan Shen, Shaojun Chen, Zaochuan Ge, Shiguo Ch
關鍵字:Chitosan,Quaternary phosphonium,Antibacterial,Water solubility
論文來源:期刊
具體來源:Materials Science and Engineering C: Materials for Biological Applications
發表時間:2016年


Chitosan (CS) has been widely recognized as an important biomaterial due to its good antimicrobial activity, biocompatibility and biodegradability. However, CS is insoluble in water in neutral and alkaline aqueous solution due to the linear aggregation of chain molecules and the formation of crystallinity. This is one of the key factors that limit its practical applications. Therefore, improving the solubility of CS in neutral and alkaline aqueous solution is a primary research direction for biomedical applications. In this paper, a reactive antibacterial compound (4-(2,5-Dioxo-pyrrolidin-1-yloxycarbonyl)-benzyl)-triphenyl-phosphonium bromide (NHS-QPS) was synthesized for chemical modification of CS, and a series of novel polymeric antimicrobial agents, Nquaternary phosphonium chitosan derivatives (N-QPCSxy, x=1–2,y= 1–4) were obtained. The water solubilities and antibacterial activities of N-QPCSxy against Escherichia coli and Staphylococcus aureus were evaluated compare to CS. The water solubility of N-QPCSxy was all better than that of CS at neutral pH aqueous solution, particularly, N-QPCS14 can be soluble in water over the pH range of 3 to 12. The antibacterial activities of CS derivatives were improved by introducing quaternary phosphonium salt, and antibacterial activity of NQPCSxy increases with degree of substitution. Overall, N-QPCS14 represents a novel antibacterial polymer material with good antibacterial activity, waters solubility and low cytotoxicity.

Copyright © 2005 Polymer.cn All rights reserved
中國聚合物網 版權所有
經營性網站備案信息

京公網安備11010502032929號

工商備案公示信息

京ICP證050801號

京ICP備12003651號

主站蜘蛛池模板: 扶余县| 海晏县| 南平市| 阿拉善左旗| 望奎县| 涟源市| 公主岭市| 祁东县| 南汇区| 陇川县| 临夏市| 二连浩特市| 高要市| 山阴县| 自贡市| 济源市| 长治县| 贡山| 娱乐| 虹口区| 运城市| 浪卡子县| 临高县| 武强县| 新巴尔虎右旗| 鄱阳县| 滨海县| 安阳县| 广灵县| 大姚县| 晋江市| 北碚区| 同江市| 万全县| 微山县| 乌拉特前旗| 旺苍县| 吴桥县| 惠安县| 义马市| 旺苍县|