私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

當(dāng)前位置:群英聚首 > 論文著作 > 正文
Enhanced water-solubility and antibacterial activity of novel chitosan derivatives modified with quaternary phosphonium salt
來源:陳仕國教授個人網(wǎng)站 發(fā)布日期:2018-01-02
作者:Dan Zhu, Honghao Cheng, Jianna Li, Wenwen Zhang, Yuanyuan Shen, Shaojun Chen, Zaochuan Ge, Shiguo Ch
關(guān)鍵字:Chitosan,Quaternary phosphonium,Antibacterial,Water solubility
論文來源:期刊
具體來源:Materials Science and Engineering C: Materials for Biological Applications
發(fā)表時間:2016年


Chitosan (CS) has been widely recognized as an important biomaterial due to its good antimicrobial activity, biocompatibility and biodegradability. However, CS is insoluble in water in neutral and alkaline aqueous solution due to the linear aggregation of chain molecules and the formation of crystallinity. This is one of the key factors that limit its practical applications. Therefore, improving the solubility of CS in neutral and alkaline aqueous solution is a primary research direction for biomedical applications. In this paper, a reactive antibacterial compound (4-(2,5-Dioxo-pyrrolidin-1-yloxycarbonyl)-benzyl)-triphenyl-phosphonium bromide (NHS-QPS) was synthesized for chemical modification of CS, and a series of novel polymeric antimicrobial agents, Nquaternary phosphonium chitosan derivatives (N-QPCSxy, x=1–2,y= 1–4) were obtained. The water solubilities and antibacterial activities of N-QPCSxy against Escherichia coli and Staphylococcus aureus were evaluated compare to CS. The water solubility of N-QPCSxy was all better than that of CS at neutral pH aqueous solution, particularly, N-QPCS14 can be soluble in water over the pH range of 3 to 12. The antibacterial activities of CS derivatives were improved by introducing quaternary phosphonium salt, and antibacterial activity of NQPCSxy increases with degree of substitution. Overall, N-QPCS14 represents a novel antibacterial polymer material with good antibacterial activity, waters solubility and low cytotoxicity.

Copyright © 2005 Polymer.cn All rights reserved
中國聚合物網(wǎng) 版權(quán)所有
經(jīng)營性網(wǎng)站備案信息

京公網(wǎng)安備11010502032929號

工商備案公示信息

京ICP證050801號

京ICP備12003651號

主站蜘蛛池模板: 扶沟县| 虹口区| 璧山县| 贡山| 兴城市| 历史| 新邵县| 特克斯县| 丹棱县| 湘乡市| 尉犁县| 鸡东县| 富川| 渝中区| 宁化县| 石台县| 成武县| 六安市| 辽阳市| 胶南市| 怀集县| 上杭县| 土默特右旗| 惠来县| 衢州市| 大同县| 弥渡县| 宁都县| 崇文区| 浦县| 兴化市| 石屏县| 东台市| 泽普县| 信阳市| 阿克陶县| 荆门市| 新疆| 北川| 东海县| 西峡县|