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Macromolecular Bioscience 2010: Improving gene delivery efficiency of bioreducible poly(amidoamine)s via grafting with dendritic poly(amidoamine)s
來(lái)源:黃世文教授個(gè)人網(wǎng)站 發(fā)布日期:2010-01-07
作者:Xue YN, Liu M, Peng L, Huang SW*, Zhuo RX
關(guān)鍵字:Gene delivery, polycation, bioreducible
論文來(lái)源:期刊
具體來(lái)源:Macromolecular Bioscience, 2010, 10, 404-414.
發(fā)表時(shí)間:2010年

Dendritic poly(amidoamine)s (PAMAM)s were introduced into the side chains of disulfide-containing poly(amidoamine)s via repetitive Michael addition and amidation. The bioreducible poly(amidoamine)s grafted with dendritic polyamidoamines showed high buffer capacity, low cytotoxicity and strong DNA binding ability at low N/P ratio. They were able to condense DNA into small sized polycation/DNA complexes, which degraded and released the incorporated DNA under reductive conditions. In comparison to the original disulfide-containing poly(amidoamine) with aminoethyl side chain, the grafting of the bioreducible poly(amidoamine) with dendrimer greatly improved the transfection efficiencies of 293T and HeLa cells with foreign DNA at various N/P ratios. The structure-gene delivery property relations of dendrimer-grafted polycations will provide valuable insight into the design of highly efficient and less toxic polycationic gene carriers.

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