私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

當(dāng)前位置:群英聚首 > 論文著作 > 正文
Reverse polymeric micelles for pharmaceutical applications.
來源:高輝教授個(gè)人網(wǎng)站 發(fā)布日期:2010-05-17
作者:M.-C. Jones, H. Gao, J.-C. Leroux,
關(guān)鍵字:poly(glycidyl methacrylate)s, star-shaped polymers, reverse micelles, water-free formulation, peptide
論文來源:期刊
具體來源:J. Controlled release , 2008;132:208-215.
發(fā)表時(shí)間:2008年

Star-shaped (4- to 8-arms) and linear poly(glycidyl methacrylate)s were synthesized by atom transfer radical polymerization as precursors of poly(glycerol methacrylate)s (PGOHMAs). The water-soluble PGOHMA backbones were modified through the esterification of pendant hydroxyl functions with acyl chlorides (12 to 18 carbons). Alkyated PGOHMAs were shown to self-assemble into reverse micelles (RMs) in organic solvents and/or oil. The resulting nanosized aggregates (20–60 nm) were able to reversibly extract anionic dyes from water and solubilise them in an organic phase. Furthermore, the encapsulation of vasopressin, a model peptide, in RMs significantly improved its solubility in an oily vehicle. This observation led to the
development of water-free peptide formulations. In vitro release studies showed that the entrapped peptide slowly diffused out of an oily RM solution (b15% in 7 days). The release rate could be significantly increased upon emulsification of the oleaginous phase. In vivo, the subcutaneous administration of loaded RMs to rats
significantly prolonged the pharmacological effect of vasopressin (N48 h vs. 8–10 h for an aqueous solution). These results highlight the ability of RMs to act as solubilizers for hydrophilic solutes in organic media, a property that may be exploited for applications in organic chemistry and pharmaceutical technology.

Copyright © 2005 Polymer.cn All rights reserved
中國(guó)聚合物網(wǎng) 版權(quán)所有
經(jīng)營(yíng)性網(wǎng)站備案信息

京公網(wǎng)安備11010502032929號(hào)

工商備案公示信息

京ICP證050801號(hào)

京ICP備12003651號(hào)

主站蜘蛛池模板: 襄城县| 汉阴县| 温泉县| 高邮市| 五莲县| 那曲县| 屏边| 民乐县| 榆树市| 隆林| 阳原县| 泰顺县| 新建县| 旌德县| 松原市| 蒙阴县| 内黄县| 正定县| 灵宝市| 垫江县| 台南县| 青海省| 上犹县| 义马市| 肇州县| 平湖市| 五常市| 德清县| 民丰县| 江孜县| 宁明县| 韶山市| 新郑市| 宁化县| 法库县| 裕民县| 修武县| 姜堰市| 贵定县| 青州市| 阿拉善盟|