私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

當(dāng)前位置:群英聚首 > 論文著作 > 正文
Biodegradable nano-composite polymer scaffolds for bone tissue engineering
作者:7. Peibiao Zhang, Yang Cui, Zhi Wang, Xin Wang, Xiuli Zhuang, and Xuesi Chen
關(guān)鍵字:poly(lactide-co-glycolide), hydroxyapatite, nano-composite, bone repair
論文來源:會議
具體來源:The 5th Asian International Symposium on Biomaterials. Xiamen China, November 15~18
發(fā)表時間:2006年
 

Although hydroxyapatite (HA) ceramics has good osteoconductivity and osteoinductivity, the brittleness and fatigue failure in the body limit their clinical applications. Recent development of biodegradable polymers, mainly polyesters such as poly(L-lactic acid ) (PLLA), poly(glycolic acid) (PGA) and their copolymers (PLGA), is an attractive approach for tissue engineering with a wide range of mechanical properties, better biocompatibility and unlimited availability. Combination of HA particles and the polymers provides a new stragety to improve their biocompatibility and mechanical properties. However, the interface compatibility of the blend only left lower uniformity and limited mechanical properties. A novel nano-composites of PLLA/gHA were obtained in our lab through the hydroxyl groups on the surface of the HA nano-particles grafted with poly(L-lactide)(PLLA), and its blend with poly(lactide-co-glycolide) (PLGA) were achieved with higher mechanical property and stability. The blend was fabricated into porous scaffolds for bone tissue engineering by porogen leaching method. The growth factor(BMP-2) and RGD copolymer were incorporated into the scaffolds to improve their biological activities. Osteoblasts adhesion, growth and differentiation in the scaffolds were investigated by morphological analysis, RT-PCR and AKP detection. The scaffolds were seeded with autogenic MSCs of rabbits in vitro, and grafted to repair the bone defects of rabbits. The results showed that MSCs attached and grew well in the scaffolds in vitro, and new bones were formed and fused in the area of bone defects rapidly in animal tests. The material showed a wide application in tissue engineering and clinical orthopaedics.

Copyright © 2005 Polymer.cn All rights reserved
中國聚合物網(wǎng) 版權(quán)所有
經(jīng)營性網(wǎng)站備案信息

京公網(wǎng)安備11010502032929號

工商備案公示信息

京ICP證050801號

京ICP備12003651號

主站蜘蛛池模板: 甘南县| 罗山县| 永修县| 武清区| 雷波县| 买车| 进贤县| 遵义市| 甘肃省| 和田市| 卓资县| 海伦市| 齐齐哈尔市| 会同县| 江门市| 淅川县| 沁阳市| 新宁县| 龙口市| 仙居县| 平遥县| 额敏县| 华阴市| 泗洪县| 北票市| 嘉义市| 临洮县| 会东县| 饶河县| 错那县| 祁东县| 宿州市| 吉隆县| 嫩江县| 大姚县| 兴国县| 任丘市| 普定县| 诏安县| 关岭| 会同县|