私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

當前位置:群英聚首 > 論文著作 > 正文
ChemEurJ--Cyclodextrin-derived mimic of glutathione peroxidase exhibiting enzymatic specificity and high catalytic efficiency
來源:董澤元教授個人網站 發布日期:2014-10-20
作者:Dong, ZY; Huang, X; Mao, SZ; et al.
關鍵字:Cyclodextrin, Glutathione Peroxidase, Artificial Enzymes
論文來源:期刊
發表時間:2006年
To elucidate the relationships between molecular recognition and catalytic ability, we chose three assay systems using three different thiol substrates, glutathione (GSH), 3-carboxyl-4-nitrobenzenethiol (CNBSH), and 4-nitrobenzenethiol (NBSH), to investigate the glutathione peroxidase (GPx) activities of 2,2′-ditellurobis(2-deoxy-β-cyclodextrin) (2-TeCD) in the presence of a variety of structurally distinct hydroperoxides (ROOH), H2O2, tert-butyl peroxide (tBuOOH), and cumene peroxide (CuOOH), as the oxidative reagent. A comparative study of the three assay systems revealed that the cyclodextrin moiety of the GPx mimic 2-TeCD endows the molecule with selectivity for ROOH and thiol substrates, and hydrophobic interactions are the most important driving forces in 2-TeCD complexation. Furthermore, in the novel NBSH assay system, 2-TeCD can catalyze the reduction of ROOH about 3.4×105 times more efficiently than diphenyl diselenide (PhSeSePh), and its second-order rate constants for thiol are similar to some of those of native GPx. This comparative study confirms that efficient binding of the substrate is essential for the catalytic ability of the GPx mimic, and that NBSH is the preferred thiol substrate of 2-TeCD among the chosen thiol substrates. Importantly, the proposed mode of action of 2-TeCD imitates the role played by several possible noncovalent interactions between enzymes and substrates in influencing catalysis and binding.
Copyright © 2005 Polymer.cn All rights reserved
中國聚合物網 版權所有
經營性網站備案信息

京公網安備11010502032929號

工商備案公示信息

京ICP證050801號

京ICP備12003651號

主站蜘蛛池模板: 吉林省| 新巴尔虎左旗| 托克托县| 泗水县| 海丰县| 永清县| 黔南| 乌兰察布市| 辉县市| 和硕县| 乐清市| 勐海县| 昭通市| 清原| 东山县| 砀山县| 汉沽区| 湖北省| 建平县| 临安市| 英吉沙县| 明星| 肥城市| 南开区| 顺义区| 镇宁| 克山县| 漳浦县| 青浦区| 宁德市| 永定县| 左权县| 固原市| 安陆市| 牡丹江市| 东乌| 乐山市| 修武县| 准格尔旗| 井研县| 尚志市|