私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

當前位置:群英聚首 > 論文著作 > 正文
A mussel-inspired double-crosslinked tissue adhesive intended for internal medical use
來源:范長江講師個人網站 發布日期:2016-08-11
作者:Changjiang Fan, Jiayin Fu, Wenzhen Zhu, Dong-An Wang
關鍵字:Tissue adhesive, Dopamine
論文來源:期刊
發表時間:2016年

It has been a great challenge to develop aldehyde-free tissue adhesives that can function rapidly and controllably

on wet internal tissues with fine adhesion strength, sound biocompatibility and degradability.

To this end, we have devised a mussel-inspired easy-to-use double-crosslink tissue adhesive (DCTA)

comprising a dopamine-conjugated gelatin macromer, a rapid crosslinker (namely, Fe3+), and a longterm

acting crosslinker (namely, genipin). As a mussel-inspired gluing macromer, dopamine is grafted

onto gelatin backbone via an one-step reaction, the catechol groups of which are capable of performing

strong wet adhesion on tissue surfaces. By addition of genipin and Fe3+, the formation of catechol–Fe3+

complexation and accompanying spontaneous curing of genipin-primed covalent crosslinking of gluing

macromers in one pot endows DCTA with the double-crosslink adhesion mechanism. Namely, the reversible

catechol–Fe3+ crosslinking executes an controllable and instant adhesive curing; while genipininduced

stable covalent crosslinking promises it with long-term effectiveness. This novel DCTA exhibits

significantly higher wet tissue adhesion capability than the commercially available fibrin glue when

applied on wet porcine skin and cartilage. In addition, this DCTA also demonstrates fine elasticity, sound

biodegradability, and biocompatibility when contacting in vitro cultured cells and blood. In vivo biocompatibility

and biodegradability are checked and confirmed via trials of subcutaneous implantation in

nude mice model. This newly developed DCTA may be a highly promising product as a biological glue

for internal medical use including internal tissue adhesion, sealing, and hemostasis.


Copyright © 2005 Polymer.cn All rights reserved
中國聚合物網 版權所有
經營性網站備案信息

京公網安備11010502032929號

工商備案公示信息

京ICP證050801號

京ICP備12003651號

主站蜘蛛池模板: 南平市| 金沙县| 乳山市| 西藏| 田东县| 白玉县| 通道| 吉木萨尔县| 光山县| 万盛区| 渭源县| 都匀市| 开原市| 怀柔区| 德安县| 云霄县| 碌曲县| 永兴县| 桂东县| 蚌埠市| 静乐县| 西城区| 金塔县| 天峻县| 浮梁县| 华容县| 尉氏县| 金华市| 收藏| 洛川县| 永福县| 枣阳市| 福州市| 大安市| 沙田区| 漳平市| 美姑县| 长泰县| 彭州市| 屏南县| 阿图什市|