Redox-responsive polyanhydride micelles for cancer therapy
作者：1. Jie Wang, Guang Yang, Xing Guo, Zhaomin Tang, Zhendong Zhong, Shaobing Zhou*
關(guān)鍵字：Micelle,redox-responsive,drug delivery,
論文來源：期刊
具體來源：Biomaterials, 2014, 35, 3080-3090.
發(fā)表時間：2014年
Biodegradable polyanhydrides possess unique features like those that they can predominantly undergo
surface erosion, and the payloads can be released by a steady speed. However, there is little work that has
been published to describe the polyanhydride micelles with redox-responsiveness as a nanocarrier for
drug delivery. In this study, we develop one type of new amphiphilic polyanhydride copolymer con-
taining disul fi de bonds between the hydrophilic and hydrophobic segments. The copolymer can self-
assemble into stable micelles with well-de fi ned coreeshell structure and a uniform size distribution
with an average diameter of 69 nm. The disassembly behaviors of the micelles triggered by glutathione
are evaluated from the changes of the micellar size, morphology and molecular weight. An approximate
zero-order in vitro drug release mode with a fast speed can be achieved in a reducing and acid envi-
ronment similar with that of tumor cells. In vitro cytotoxicity analysis demonstrate that the Cur-loaded
micelles are of great ef fi ciency in inhibiting the growth of cancer cells due to the rapidly intracellular
delivery of therapeutic agent. Both the qualitative and quantitative results of the antitumor activity in
4T1 tumor-bearing BALB/c mice reveal that the redox-responsive micelles have a more signi fi cant
therapeutic effect to arti fi cial solid tumor compared to the redox-insensitive micelles. This study pro-
vides a new insight into the biomedical application of polyanhydrides in drug delivery.