Biocompatible Injectable Magnetic Hydrogel Formed by Dynamic Coordination Network
writer：L Shi, Y Zeng, Y Zhao, B Yang, D Ossipov, CW Tai, J Dai, C Xu
keywords：Magnetic Hydrogel, Injectable, Biocompatible, Self-healing, Dynamic Coordination Bonds
source：期刊
Issue time：2019年
Magnetic hydrogel that can respond for magnetic stimulus is a promising biomaterial for tissue regeneration and cancer treatment. In this study, a novel magnetic hydrogel is formed by simply mixing bisphosphonate (BP) modified hyaluronic acid (i.e. HA-BP) polymeric solution and iron oxide (Fe3O4) nanoparticle dispersion, in which the hydrogel networks are crosslinked by BP groups and iron atoms on the surface of particle. The iron-BP coordination chemistry affords a dynamic network, characterized by self-healing, shear-thinning, and smoothly-injectable properties. Moreover, the HA-BP?Fe3O4 magnetic hydrogel demonstrates heat-generation characterization under an alternating magnetic field. The animal experiments confirm the biocompatibilities of HA-BP?Fe3O4 hydrogel which presents the hydrogels potential for tissue regeneration and anti-cancer treatment applications.