私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

當(dāng)前位置:> 首頁 > 論文著作 > 正文
Pharmaceutical Research, 2011, 28(6), 1294-1305; Synthesis of Temperature-Responsive Dextran-MA/PNIPAAm Particles for Controlled Drug Delivery Using Superhydrophobic Surfaces,
作者:A. C. Lima, Wenlong Song, B. Blanco-Fernandez, C. Alvarez-Lorenzo, J. F. Mano,
關(guān)鍵字:superhydrophobic, hydrogel bead, pnipaam hydrogel
論文來源:期刊
發(fā)表時間:2015年

Purpose

To implement a bioinspired methodology using superhydrophobic surfaces suitable for producing smart hydrogel beads in which the bioactive substance is introduced in the particles during their formation.

Methods

Several superhydrophobic surfaces, including polystyrene, aluminum and copper, were prepared. Polymeric solutions composed by photo-crosslinked dextran-methacrylated and thermal responsive poly(N-isopropylacrylamide) mixed with a protein (insulin or albumin) were dropped on the superhydrophobic surfaces, and the obtained millimetric spheres were hardened in a dry environment under UV light.

Results

Spherical and non-sticky hydrogels particles were formed in few minutes on the superhydrophobic surfaces. The proteins included in the liquid formulation were homogeneously distributed in the particle network. The particles exhibited temperature-sensitive swelling, porosity and protein release rate, with the responsiveness tunable by the dextran-MA/PNIPAAm weight ratio.

Conclusions

The proposed method permitted the preparation of smart hydrogel particles in one step with almost 100% encapsulation yield. The temperature-sensitive release profiles suggest that the obtained spherical-shaped biomaterials are suitable as protein carriers. These stimuli-responsive beads could have potential to be used in pharmaceutical or other biomedical applications, including tissue engineering and regenerative medicine.

主站蜘蛛池模板: 来安县| 元谋县| 页游| 邵阳市| 嘉义市| 云梦县| 桂阳县| 肇州县| 郧西县| 通江县| 武功县| 延寿县| 浦江县| 嘉善县| 双鸭山市| 合肥市| 延川县| 枝江市| 马龙县| 浦东新区| 秭归县| 正镶白旗| 丽水市| 长武县| 荣昌县| 绍兴市| 麻栗坡县| 宁城县| 彭泽县| 固原市| 平和县| 施甸县| 广灵县| 嘉荫县| 巧家县| 庆云县| 漳平市| 重庆市| 宣汉县| 新民市| 民丰县|