Formation and enhanced biocidal activity of water-dispersible organic nanoparticles
作者：hang, Haifei; Wang, Dong; Butler, Rachel; Campbell, Neil L.; Long, James; Tan, Bien; Duncalf, David
關鍵字：Nanoparticles
論文來源：期刊
具體來源：Nature Nanotechnology (2008), 3(8), 506-511.
發表時間：2009年
Water-insol. org. compds. are often used in aq. environments in various pharmaceutical and consumer products. To overcome insoly., the particles are dispersed in a medium during product formation, but large particles that are formed may affect product performance and safety. Many techniques have been used to produce nanodispersions-dispersions with nanometer-scale dimensions-that have properties similar to solns. However, making nanodispersions requires complex processing, and it is difficult to achieve stability over long periods. Here we report a generic method for producing org. nanoparticles with a combination of modified emulsion-templating and freeze-drying. The dry powder composites formed using this method are highly porous, stable and form nanodispersions upon simple addn. of water. Aq. nanodispersions of Triclosan (a com. antimicrobial agent) produced with this approach show greater activity than org./aq. solns. of Triclosan. Aq. dispersions of nanoparticles of Triclosan - a com. antimicrobial agent - display better biocidal activity than org. solns. of the same agent. The nanoparticles are produced by a combination of modified emulsion-templating and freeze-drying.