Ugi Reaction of Natural Amino Acids: A General Route toward Facile Synthesis of Polypeptoids for Bioapplications.
writer：ZHANG Xiaojie, WANG Shixue, LIU Jing, XIE Zhigang, LUAN Shifang, XIAO Chunsheng, TAO Youhua*,WANG Xi
keywords：Ugi Reaction
source：期刊
specific source：ACS Macro Letters
Issue time：2016年
Polypeptoids represent a significant class of synthetic analogues of natural polypeptides with potential biomimetic applications in materials, catalysis, and pharmaceuticals, but their simple and general synthesis still remains a key challenge. Herein, we demonstrate that Ugi reaction of natural amino acids leads to structurally diverse polypeptoids, including γ- and δ-, as well as poly(ε-peptoid)s, under mild conditions (open to air, room temperature, and catalyst free).