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課題組關于利用光控主客體相互作用改進具有“呼吸”特性的中空聚合物納米微球的制備并將其用于藥物控釋的研究工作被J. Mater. Chem. B錄用

Photo-controlled host–guest interaction as a new strategy toimprove the preparation of “breathing” hollow polymernanospheres as controlled drug delivery

Haitao Zhang, Wei Tian,* RongtianSuo, Yang Yue, Xiaodong Fan, Zhen Yang, Hui Li, Wanbin Zhang,and Yang Bai

This paper presents the photo-controlled host–guest interaction between azobenzene and β-cyclodextrin as a newstrategy to improve the method for core removal to preparepoly((itaconoyloxy)ethylmethacrylate)-block-poly(Nisopropylacrylamide-based hollownanospheres. This improved method for the preparation of hollow nanospheres issimple,environment friendly, and highly efficient. The resulting hollow nanospheres displayed a typical“breathing”behavior, which further induces the controlled release of doxorubicin hydrochloride. Cellular toxicity evaluationindicated that the hollow nanospheres possess good biocompatibilityand can be used as a promising doxorubicinhydrochloride carrier.

全文鏈接:http://pubs.rsc.org/en/content/articlelanding/2014/TB/C5TB01665G#!divAbstract

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