私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

相關鏈接
聯系方式
  • 通信地址:陜西省西安市長安區西北工業大學化學與化工學院
  • 郵編:710129
  • 電話:13772401347
  • 傳真:
  • Email:happytw_3000@163.com
當前位置:> 首頁 > 論文著作 > 正文
[Adv. Funct. Mater.]Cation-π Interaction-Mediated Tumour Drug Delivery for Deep Intratumoral Penetration and Treatment
作者:Chengfei Liu, Muqiong Li, Jianxiang Sun, Li Fan,* and Wei Tian*
關鍵字:Cation-π Interaction,Tumour Drug Delivery,Deep Intratumoral Penetration
論文來源:期刊
具體來源:Adv. Funct. Mater. 2022, 32, 2205043
發表時間:2022年

   The limited efficacy of deep tumor treatments has been considered the “Achilles’ heel” of anticancer therapy due to multiple biological barriers. Whether passive diffusion or active transport has difficulties completely overcoming these obstacles. Herein, cation-π interactions are utilized to construct a tumor drug delivery system integrating the merits of both passive and active transport mechanisms. A cation-π interaction bridged trimetallic supramolecular drug complex (Cπ-TMSDC) is constructed based on a drug consisting of one cisplatin molecule linked by K+ (Pt-COOK) and the other drug with a Ru metal complex containing curcumin (Ru-Cur). The obtained Cπ-TMSDC further self-assembles into cation-π-based trimetallic supramolecular drug micelles (Cπ-TMSDMs) with efficient and stable transportation in vivo due to the strong cation-π interaction formed between K+ and the curcumin unit in the Cπ-TMSDC. In acidic tumor microenvironment, the cation-π interaction smartly dissociates, facilitating the quick release of Pt-COOK outside Cπ-TMSDMs to rapidly infiltrate the outer cellular layers by passive diffusion. Meanwhile, the dissociated Ru-Cur from the core layer of the Cπ-TMSDMs form secondary self-assemblies to deeply penetrate inside the solid tumor. Therefore, this strategy results in an efficient tumor drug delivery platform with enhanced deep intratumoral penetration, improved therapeutic effects, and reduced systemic toxicity to normal organs.


全文鏈接: https://doi.org/10.1002/adfm.202205043.

主站蜘蛛池模板: 读书| 正宁县| 城固县| 江西省| 屯昌县| 康保县| 南安市| 胶州市| 祁门县| 宜兴市| 墨脱县| 新建县| 麻阳| 工布江达县| 天水市| 耒阳市| 宝清县| 色达县| 获嘉县| 南通市| 永兴县| 西乡县| 和平区| 嘉祥县| 武威市| 于田县| 云林县| 定兴县| 陇西县| 绍兴市| 商水县| 龙山县| 龙海市| 综艺| 托克逊县| 鄂伦春自治旗| 竹北市| 伽师县| 昌都县| 玉林市| 岐山县|