Chitin Nanocrystals-Stabilized Emulsion as Template for Fabricating Injectable Suspension Containing Polylactide Hollow Microspheres
作者：Sumin Yu, Guangni Peng, Jiali Jiao, Peng Liu, Huajun Li, Juqun Xi, Defeng Wu*
關鍵字：chitin nanocrystals; surface acetylation; Pickering emulsions; polylactide microspheres; dermal fillers.
論文來源：期刊
具體來源：Carbohydrate Polymers
發表時間：2024年
Carbohydrate Polymers, 2024, 337, 122176.
One of the promising applications of rod-like chitin nanocrystals (ChNCs) is the use as particle emulsifier to develop Pickering emulsions. We reported a ChNC-stabilized oil-in-water emulsion system, and developed a Pickering emulsion-templated method to prepare polylactide (PLA) hollow microspheres here. The results showed that both non-modified ChNCs and acetylated ChNCs could well emulsify the dichloromethane (DCM) solution of PLA-in-aqueous mannitol solution systems, forming very stable emulsions. At the same oil-to-water ratios and ChNC loadings, the emulsion stability was improved with increasing acetylation levels of ChNCs, accompanied by reduced size of droplets. Through the solvent evaporation, the PLA hollow microspheres were templated successfully, and the surface structure was also strongly dependent on the acetylation level of ChNCs. At a low level of acetylation, the single-hole or multi-hole surface structure formed, which was attributed to the out-diffusion of DCM caused by the solvent extraction and evaporation. These surface defects decreased with increased acetylation levels of ChNCs. Moreover, the aqueous suspension with as-obtained PLA microspheres revealed shear-thinning property and good biocompatibility, thereby had promising application as injectable fillers. This work can provide useful information around tuning surface structures of the Pickering emulsion-templated polymer hollow microspheres by regulating acetylation level of ChNCs.
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https://www.sciencedirect.com/science/article/pii/S0144861724004028