Direct Aqueous Self-Assembly of an Amphiphilic Diblock Copolymer toward Multistimuli-Responsive Fluorescent Anisotropic Micelles
writer：Gang Wu, Si-Chong Chen, Chang-Lei Liu, and Yu-Zhong Wang
keywords：shape anisotropy，fluorescent，micelles，stimuli-responsive，block copolymers，self-assembly
source：期刊
specific source：ACS Nano
Issue time：2015年
It is extremely important for emerging applications and still enormously challenging to develop multifunctional stimuli-responsive anisotropic polymeric micelles with integration of potentially targeted therapeutic and diagnostic function. Herein, we report a first example of fluorescent anisotropic micelles (FAMs) with Fe3+, DTT, H2O2, and thermal responsive fluorescence and morphology. FAMs from direct aqueous self-assembly of amphiphilic diblock copolymer showed reversible “switch off/on” of aqua fluorescent emission and controllable structural change by sequential addition of Fe3+ and DTT. In addition, the FAMs had reversible dual-thermal responsiveness of fluorescence and morphology. This micelle could serve as a promising candidate for all-in-one application of quantitative detecting, imaging, drug delivery, and targeted release.
