私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

相關鏈接
聯系方式
  • 通信地址:吉林省吉林市龍潭區承德街45號
  • 郵編:132022
  • 電話:0432-25358645
  • 傳真:
  • Email:yhyqdu@163.com
當前位置:> 首頁 > 論文著作 > 正文
Green preparation of pH-responsive and dual targeting hyaluronic acid nanogels for efficient protein delivery
作者:Hong Yu Yang,Yi Li,Moon-Sun Jang,Yan Fu,Jung Hee Lee,Doo Sung Lee
關鍵字:dual targeting ,nanogel
論文來源:期刊
具體來源:https://doi.org/10.1016/j.eurpolymj.2019.109342
發表時間:2019年
PEGylated protein delivery systems that effectively improve the efficiency of protein delivery often suffer limitations of uncontrollable release and non-targeting. In this study, pH-responsive nanogels are developed by forming benzoic imine bonds between hyaluronic acid-graft-methoxy poly(ethylene glycol)-diethylenetriamine (HA-PEG-Diet) copolymers and terephthalaldehyde (TPA) crosslinkers for dual-targeting protein delivery. Cytochrome C (CC), a protein drug, could be facilely encapsulated into the nanogels with a high loading efficiency. Under a physiological environment, these nanogels exhibit excellent stability due to the presence of hydrophobic cores. However, under an acidic tumor microenvironment, the nanogels can undergo pH-induced cleavage of benzoic imines that initiates surface charge conversion from negative to positive, thus promoting cell uptake and protein release. Importantly, confocal images and cytotoxicity results confirm that CC-loaded nanogels can effectively target and eliminate CD44-positive cancer cells via pH-induced surface charge switching and CD44 receptors on cell surfaces. Thus, these pH-responsive dual-targeted nanogels prepared through a green method, have great potential for protein delivery and cancer therapy.
主站蜘蛛池模板: 普兰县| 资中县| 洛阳市| 康马县| 汉沽区| 寻乌县| 铜鼓县| 瑞金市| 龙门县| 长丰县| 富裕县| 繁峙县| 昌黎县| 天峻县| 昌都县| 沂水县| 凤城市| 兴业县| 星子县| 城步| 平舆县| 襄汾县| 衡南县| 江城| 鲁山县| 罗甸县| 南开区| 宜阳县| 贵港市| 玛曲县| 潜江市| 青铜峡市| 广饶县| 建水县| 吉木萨尔县| 宣武区| 南通市| 鹰潭市| 含山县| 桓台县| 遂溪县|