私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

當前位置:> 首頁 > 論文著作 > 正文
Magnetic core-shell S-nitrosothiols nanoparticles as tumor dual-targeting theranostic platform
作者:Tuanwei Liu, Ping Zhang, Xiaoying Huang, Xiaoxuan Chi, Zinan Li, Zhide Zhang, Dian-Shun Guo, Xinlin
關鍵字:Nitric oxide, targeting theranostic, synergistic effect, core-shell magnetic nanoparticles
論文來源:期刊
具體來源:Colloid Surf. B 173 (1), 356-365 (2019). https://doi.org/10.1016/j.colsurfb.2019.05.075
發表時間:2019年

The external force guided targeting strategy, as well as the in vivo active targeting

strategy based on “ligands-receptors” on the targeting cells and tissues have attracted

much research interest. Herein, a kind of hyaluronic acid (HA) and folic acid (FA)

modified magnetic S-nitrosothiols core-shell nanoparticles for nitric oxide (NO)

control release as dual-tumor targeting theranostic platform were described,

combining the external guidance and internal active targeting properties. Confocal

microscopy assay and cells cytotoxicity experiments confirmed the active tumor cells

targeting recognition, cells uptake, and NO initiated cytotoxicity of the HA-FA

external functional layer modified S-nitrosothiols nanoparticles in vitro. In vivo

magnetic resonance imaging (MRI) characterization, bio-distribution assay in organs

and tumor, significant tumor inhibition efficacy, survival units of the mice bearing

tumor, as well as the systemic toxicity assay demonstrated the efficiency of

cooperative tumor targeting diagnosis and controlled NO-releasing chemotherapy. To

the best of our knowledge, this is the first time of the external magnet and HA-FA

actively induced synergistic effect tumor targeting systems based on NO

chemotherapy in vivo, serving as a new theranostic system.


主站蜘蛛池模板: 河间市| 廊坊市| 嘉兴市| 苗栗县| 花垣县| 高雄县| 依兰县| 兰考县| 监利县| 常宁市| 洪江市| 连平县| 英德市| 金溪县| 龙口市| 开封县| 天长市| 铁力市| 伊春市| 南宫市| 峨山| 固原市| 夏河县| 洛隆县| 视频| 花莲市| 达州市| 济宁市| 双峰县| 张家界市| 彰化县| 北票市| 遵化市| 余姚市| 镇坪县| 济源市| 牙克石市| 香河县| 沅江市| 邻水| 通江县|