私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

當(dāng)前位置:> 首頁 > 論文著作 > 正文
Preparation of amphiphilic superparamagnetic composite particles with tumor targeted MRI contrast agent
作者:Gu Jun-heng, Zhang Qing-yun, Zhang Wei, Yang Xin-lin
關(guān)鍵字:tumor; molecular targeted therapy; metal nanoparticles; folic acid
論文來源:期刊
具體來源:Chin J Tissue Eng Res (中國(guó)組織工程) 18 (30), 4823-4830 (2014). doi:10.3969/j.issn.2095-4344.
發(fā)表時(shí)間:2014年

he Pluronic F127-folic acid conjugates were prepared via esterification reaction. Then Fe3O4 NPs were wrapped with Pluronic F127-folic acid to result in the superparamagnetic composite particles with well dispersion and biocompatibility. The size of most superparamagnetic composite particles was less than 200 nm and the size of Fe3O4 core was 10-20 nm from the observation of transmission electron microscopy. The results from the Fourier transform infrared-spectra and UV-vis absorption spectra confirmed that folic acid molecules were modified on the surface of the superparamagnetic composite particles successfully. The mass ratio of Pluronic F127-folic acid conjugate was determined by thermal gravimetric analysis as 27.2 wt% in the resultant Pluronic F127-folic acid-Fe3O4 composite particles. The saturated magnetic intensity of the superparamagnetic composite particles was 47.35 emu/g by vibrating sample magnetometer and the relaxation rate was 0.025×106/mol/s from MRI. The WST assay showed the negligible cell cytotoxicity of Pluronic F127-folic acid-Fe3O4. The superparamagnetic composite particles have potential application as the MRI contrast agents with tumor targeting, and the Pluronic F127-folic acid-Fe3O4 composite particles is expected to be used as a MRI contrast agent for tumor targeting.

主站蜘蛛池模板: 宁明县| 南丰县| 宜宾县| 东源县| 搜索| 广昌县| 台南市| 驻马店市| 元谋县| 乌什县| 新晃| 南涧| 环江| 温宿县| 屯昌县| 揭阳市| 蓝山县| 巴南区| 岳阳县| 蓬莱市| 漠河县| 包头市| 托里县| 鲁甸县| 榆中县| 从江县| 新竹县| 郁南县| 万全县| 岚皋县| 龙州县| 长治县| 从江县| 东乌珠穆沁旗| 托克托县| 杭锦后旗| 自治县| 永丰县| 潞城市| 翁源县| 泰州市|