私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

當前位置:> 首頁 > 論文著作 > 正文
Preparation of amphiphilic superparamagnetic composite particles with tumor targeted MRI contrast agent
作者:Gu Jun-heng, Zhang Qing-yun, Zhang Wei, Yang Xin-lin
關鍵字:tumor; molecular targeted therapy; metal nanoparticles; folic acid
論文來源:期刊
具體來源:Chin J Tissue Eng Res (中國組織工程) 18 (30), 4823-4830 (2014). doi:10.3969/j.issn.2095-4344.
發表時間:2014年

he Pluronic F127-folic acid conjugates were prepared via esterification reaction. Then Fe3O4 NPs were wrapped with Pluronic F127-folic acid to result in the superparamagnetic composite particles with well dispersion and biocompatibility. The size of most superparamagnetic composite particles was less than 200 nm and the size of Fe3O4 core was 10-20 nm from the observation of transmission electron microscopy. The results from the Fourier transform infrared-spectra and UV-vis absorption spectra confirmed that folic acid molecules were modified on the surface of the superparamagnetic composite particles successfully. The mass ratio of Pluronic F127-folic acid conjugate was determined by thermal gravimetric analysis as 27.2 wt% in the resultant Pluronic F127-folic acid-Fe3O4 composite particles. The saturated magnetic intensity of the superparamagnetic composite particles was 47.35 emu/g by vibrating sample magnetometer and the relaxation rate was 0.025×106/mol/s from MRI. The WST assay showed the negligible cell cytotoxicity of Pluronic F127-folic acid-Fe3O4. The superparamagnetic composite particles have potential application as the MRI contrast agents with tumor targeting, and the Pluronic F127-folic acid-Fe3O4 composite particles is expected to be used as a MRI contrast agent for tumor targeting.

主站蜘蛛池模板: 华亭县| 宁蒗| 巫山县| 邵武市| 揭西县| 永福县| 海伦市| 五华县| 东方市| 新民市| 宁武县| 湖州市| 淅川县| 英德市| 蒲江县| 宁海县| 晋江市| 西华县| 宁城县| 伊金霍洛旗| 绥江县| 贵州省| 东莞市| 浙江省| 博乐市| 玉屏| 宁南县| 会泽县| 文山县| 祁阳县| 界首市| 准格尔旗| 平定县| 图木舒克市| 祁连县| 庄浪县| 泉州市| 通渭县| 南宁市| 库尔勒市| 武山县|