私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

相關(guān)鏈接
聯(lián)系方式
  • 通信地址:南京仙林大學城南師大化科院
  • 郵編:210023
  • 電話:N
  • 傳真:
  • Email:jyuan@njnu.edu.cn
當前位置:> 首頁 > 論文著作 > 正文
49. Preparation of keratin/chlorhexidine complex nanoparticles for long-term and dual stimuli-responsive release
作者:Xuelian Zhi, Yanfang Wang, Pengfei Li, Jiang Yuan*, Jian Shen*.
關(guān)鍵字:Keratin
論文來源:期刊
具體來源:RSC Advance 2015, 5, 82334 - 82341
發(fā)表時間:2015年

Nanoscale polyion complex formed by polyelectrolyte and charged drug via electrostatic complexation is the most convenient method for building a drug delivery system to simultaneously realizes the carrier preparation and drug embedding. Herein, we prepared keratin/chlorhexidine complex nanoparticles (KCNPs) based on a drug-induced ionic gelation technique without using crosslinker, organic solvent and surfactant. These KCNPs exhibited good stability even after long-standing for 14 days. The KCNPs were characterized with FTIR, DLS, SEM and TEM. It was found that these nanoparticles had the spherical morphology with the diameter of about 180 nm, and negatively charged surface with the zeta potential of about -39.1 mV. Cell toxicity of KCNPs at different dosages level was evaluated with MTT assay method, indicating their slight cytotoxicity at lower dosage. The antibacterial activity against E. coli and S. aureus was determined using a zone of inhibition method. It seemed KCNPs had better antibacterial activity against S. aureus than E. coli. Drug delivery profile showed that chlorhexidine(CHX) loaded nanoparticles exhibited both pH and glutathione responsive. These keratin-based complex nanoparticles can be regarded as a valuable stimuli responsive strategy for the delivery of anticancer agents.

主站蜘蛛池模板: 潮州市| 格尔木市| 邮箱| 扬中市| 金寨县| 德昌县| 建德市| 鄱阳县| 丹凤县| 安西县| 朝阳区| 台东县| 洪洞县| 凤台县| 郎溪县| 寿阳县| 铁岭市| 磴口县| 忻州市| 长子县| 互助| 财经| 平山县| 武清区| 喀什市| 乌什县| 洛宁县| 榆社县| 资中县| 上蔡县| 黄冈市| 白山市| 盐亭县| 颍上县| 东源县| 永城市| 兴城市| 府谷县| 冕宁县| 沈阳市| 攀枝花市|