Facile One-Pot Synthesis of Iron Oxide Nanoparticles Cross-linked Magnetic Poly(vinyl alcohol) Gel Beads for Drug Delivery
作者：Li Zhou, Benzhao He, Faai Zhang
關鍵字：one-pot, magnetic gel bead, poly(vinyl alcohol), responsibility, drug delivery
論文來源：期刊
具體來源：ACS Applied Materials & Interfaces
發表時間：2012年
In this paper, a facile one-pot strategy for
scalable synthesis of robust magnetic poly(vinyl alcohol)
(mPVA) gel beads is developed. Through dropwise addition of
mixed aqueous solution of iron salts and PVA solution into
alkaline (e.g., ammonia, NaOH, and KOH) solution, mPVA
gel beads with uniform size and excellent superparamagnetic
property can be fabricated based on the simultaneous
formation of magnetic iron oxide nanoparticles (MIONs)
and cross-link of PVA chains. Moreover, this approach can be
extended to prepare dual- or multiresponsive gel beads
through simply adding functional fillers into PVA solution
(e.g., mPVA-PNIPAM gel beads that possess both magnetic
and temperature responsibilities can be readily prepared by
adding temperature responsive poly(N-isopropylacrylamide) (PNIPAM) into PVA solution). It is found that that the obtained
mPVA gel beads exhibit high drug loading level (e.g., above 70%) after the treatment of freezing-thawing. Drug release
experiments reveal that the drug release rate and amount of the mPVA gel beads can be tuned by operating the external magnetic
field and adjusting the concentration of iron oxide nanoparticles and temperature (for mPVA-PNIPAM gel beads). The present
work is of interest for opening up enormous opportunities to make full use of magnetic gel beads in drug delivery and other
applications, because of their facile availability, cost-effective productivity, and tunable drug release performance