私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

相關鏈接
聯系方式
  • 通信地址:天津市南開區衛津路94號,南開大學蒙民偉樓104室
  • 郵編:300071
  • 電話:022-23501645
  • 傳真:
  • Email:zhangxinge@nankai.edu.cn
當前位置:> 首頁 > 論文著作 > 正文
14. Gradient cross-linked biodegradable polyelectrolyte nanocapsules for intracellular protein drug delivery
作者:Shujun Shu, Xinge Zhang*, Zhongming Wu, Zhen Wang, Chaoxing Li*.
關鍵字:polyelectrolyte nanocapsules
論文來源:期刊
具體來源:Biomaterials, 2010, 31(23):6039-6049.
發表時間:2010年

Gradient shell cross-linked hollow polyelectrolyte nanocapsules composed of cysteamine conjugated chitosan and dextran sulfate were prepared by layer-by-layer adsorption on beta-cyclodextrin (beta-CD) functionalized silica spheres followed by cross-linking thiols and removal of silica core. This disulfide bond gradient cross-linked nanocapsules combined reduction and pH sensitive. Gradually increased from the inside to the outside of the cross-linking degree, one purpose is to ensure that cross-linking disulfide bond after reduction cleavage still has pH sensitive, on the other hand is to avoid cross-linked contraction of internal damage the crystal and bioactivity of protein drugs. Disulfide cross-linked nanocapsules were used to enhance the physical stability against acidic pH conditions compared to the un-cross-linked ones. Bovine serum albumin, as a model protein drug, was loaded inside nanocapsules. The disulfide bond cross-linked nanocapsules are intended to remain more stable in physiological pH and decrease the loss of protein drugs caused by the gastric cavity, and can release the drugs in the intracellular environment after glutathione reduction.

主站蜘蛛池模板: 偃师市| 汾西县| 陆河县| 高陵县| 晋宁县| 会昌县| 盖州市| 乳山市| 剑阁县| 水富县| 荣昌县| 武鸣县| 和龙市| 辽源市| 苏尼特右旗| 修文县| 馆陶县| 宜兰市| 瑞昌市| 安达市| 闸北区| 若羌县| 秀山| 福海县| 金秀| 喀什市| 山丹县| 阜新| 阜城县| 平乡县| 舟曲县| 武安市| 芜湖县| 乌拉特前旗| 灵璧县| 微博| 吉隆县| 新乡县| 长汀县| 普洱| 丹棱县|