私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

相關鏈接
聯系方式
  • 通信地址:天津市南開區衛津路94號,南開大學蒙民偉樓104室
  • 郵編:300071
  • 電話:022-23501645
  • 傳真:
  • Email:zhangxinge@nankai.edu.cn
當前位置:> 首頁 > 論文著作 > 正文
Biodegradable and redox-responsive chitosan/poly(L-aspartic acid) nanocapsule for transmucosal delivery of proteins and peptides.
作者:Chao Zheng, Xinge Zhang*, Zhengpu Zhang, Chaoxing Li*
關鍵字:nanoparticles, drug delivery
論文來源:期刊
具體來源:Journal of Materials Science: Materials in Medicine. 2013, in press.
發表時間:2013年

The development of peptides and proteins is hampered by their rapid clearance in liver and other body tissues by proteolytic enzymes, so these drugs are difficult to administer except for the injection. Here, we designed and fabricated a novel biodegradable and redox-responsive submicron capsules through the layer-by-layer technique with poly(L-aspartic acid) and chitosan for transmucosal delivery of proteins and peptides. TEM graphs reveal that the intact submicron capsules were obtained and the shell of submicron capsules was about 40 nm. The mucoadhesion test indicates that the adsorption amount of the mucin could achieve up to 96.2 μg per 2 mg. The cell viability test shows that all types of submicron capsules had good cytocompatibility and the cell viability was above 90 %. As a drug model, the insulin could be loaded in the submicron capsules, and the loading efficiency was about 5 %. The release amount of insulin could be regulated by the levels of GSH. Therefore, the mucoadhesive submicron capsules as vehicles have a potential for the mucosal delivery (e.g. nasal and buccal) of therapeutic peptide and protein drugs.

主站蜘蛛池模板: 敦煌市| 新津县| 资溪县| 阿拉善右旗| 新田县| 南皮县| 内黄县| 大竹县| 萨迦县| 松原市| 铁岭市| 信丰县| 广昌县| 萝北县| 宿松县| 延吉市| 滨州市| 焉耆| 丰顺县| 通江县| 丹棱县| 武鸣县| 资溪县| 朝阳区| 治多县| 永川市| 长沙市| 鲁山县| 赤城县| 凤翔县| 中方县| 航空| 噶尔县| 尚志市| 萨嘎县| 枞阳县| 措美县| 弋阳县| 霍林郭勒市| 丁青县| 台山市|