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鐐庣棁鎬ц偁鐥?/span>(inflammatory bowel disease, IBD)鏄竴縐嶅彲绱強鍥炶偁銆佺粨鑲犮佺洿鑲犵敋鑷沖叏娑堝寲閬撶殑鎱㈡с佸鍙戞х殑鐐庢х柧鐥咃紝涓昏鍖呮嫭婧冪枴鎬х粨鑲犵値(ulcerative colitis, UC)鍜屽厠緗楁仼鐥?/span>(Crohn鈥檚 disease, CD)銆傝繎騫存潵錛屾煋鏂欐湪榛勯叜錛?/span>Genistein, GEN錛夊湪棰勯槻鍜屾不鐤?/span>IBD鏂歸潰鏄劇ず鍑鴻壇濂界殑鍓嶆櫙銆備絾鏄?/span>GEN闅炬憾浜庢按錛岀洿鎺ュ彛鏈嶇殑鐢熺墿鍒╃敤搴︿綆錛屼笖楂樻祿搴?/span>GEN榪樺叿鏈夋綔鍦ㄧ殑鐢熺墿姣掓э紝闃葷浜嗗叾鍦ㄤ復搴婁腑鐨勫簲鐢ㄣ?/span>
榪戞湡錛屽崡浜啘涓氬ぇ瀛﹀姩鐗╁尰瀛﹂櫌瀹嬬礌娉夋暀鎺堝洟闃熷湪IBD鐨勯槻鎺х爺絀朵腑鍙栧緱鏂拌繘灞曘傚湪銆?/span>ACS Applied Material & Interfaces銆嬫湡鍒婁笂鍙戣〃浜嗛涓?/span> 鈥?/span>Genistein-derived ROS-responsive Nanoparticles Relieve Colitis by Regulating Mucosal Homeostasis鈥?span style="font-family:瀹嬩綋;">鐨勬枃绔?/span>(doi: 10.1021/acsami.1c0921)銆傝鏂囩殑絎竴浣滆呮槸鑼冩枃闊崥澹?/span>

璇ヨ棰樼粍涓烘彁楂?/span>GEN鐨勭敓鐗╁埄鐢ㄧ巼錛屾彁楂樺叾闈跺悜鎬э紝鍒跺浜嗗惈鏈夎秴姘у寲鐗╂鍖栭叾妯℃嫙鐗╋紙Tempol錛夊叡杞殑 尾-鐜硦綺懼拰 4-錛堢緹鐢插熀錛夎嫰鍩虹〖閰擱鍝唶閰慨楗扮殑GEN鐨?/span>ROS鍝嶅簲鍨嬬撼綾蟲潗鏂欙紙GEN-NP2錛夈傝鏉愭枡鍙互琚偁涓婄毊緇嗚優鎽勫彇騫跺湪鐐庣棁閮ㄤ綅ROS鍒烘縺涓嬮珮鏁堟竻闄ゅ悇縐嶆椿鎬ф哀鍒嗗瓙錛堝浘1錛夈傚彟澶?/span>GEN-NP2鍙互淇濇姢 GEN 鍏嶅彈鑳冭偁閬撲腑娑堝寲閰剁殑蹇熶唬璋紝浠庤屾湁鏁堝湴灝?/span>GEN 闈跺悜閫掗佽嚦鐐庣棁閮ㄤ綅錛堝浘2錛夈備粠鏈哄埗涓婅錛?/span>GEN-NP2閫氳繃澧炲姞闆屾縺绱犲彈浣?/span>尾錛?/span>ER尾錛夌殑琛ㄨ揪錛岄檷浣庝績鐐庝粙璐ㄧ殑琛ㄨ揪錛屽噺寮辯値鐥囬儴浣嶇値鐥囩粏鑳炵殑嫻告鼎錛屼績榪涜偁涓婄毊緇嗚優鐨勮嚜鍣紝鎶戝埗鐐庢х粏鑳炲洜瀛愮殑鍒嗘硨錛屽茍璋冭妭鑲犻亾寰敓鐗╃兢鐨勭ǔ鎬侊紝鏈緇堢紦瑙ｈ偁閬撶値鐥囷紙鍥?/span>3錛?/span>4錛夈傛湰鐮旂┒涓?/span> IBD 鐨勭簿紜不鐤楁彁渚涗簡涓縐嶆湁鏁堢殑鏂規錛屼負鎻愰珮涓嵂鐨勭敓鐗╁埄鐢ㄥ害錛屾不鐤楀叾瀹冧笌姘у寲搴旀縺銆佺値鐥囩浉鍏崇殑鐤劇梾鎻愪緵浜嗘濊礬銆?/span>


鍥?/span>1. GEN-NPs鍚堟垚鍙?/span>闈跺悜娌葷枟緇撹偁鐐庣殑紺烘剰鍥俱?/span>

鍥?/span> 2. GEN-NPs 闈跺悜瀹氫綅浜?span>鍏鋒湁鐐?span>鐥囧弽搴?/span>鐨勭粨鑲犮?/span>(A-D) 閫氳繃绱鍙鍏夎氨 (A鍜?/span>C) 鍜?/span>HPLC (B鍜?/span>D) 媯嫻?SGF銆?/span>SIF鍜?/span>SCF 涓?GEN-NPs 鐨勫寲瀛︾ǔ瀹氭с?/span>(E) GEN鍦ㄤ笉鍚屾ā鎷熺紦鍐叉憾娑蹭腑浠?GEN-NPs鐨勯噴鏀炬洸綰褲?/span>(F) FITC鏍囪鐨?GEN-NP1鍦ㄥ仴搴鋒垨緇撹偁鐐庡皬榧犱腑紱諱綋鎴愬儚鐨勭敓鐗╁垎甯冨垎鏋愩?/span>(G) 緇撹偁涓?/span>FITC-GEN-NP1鑽у厜淇″彿鐨勯噺鍖栥?/span>

鍥?/span>3. GEN-NPs 璋冭妭緇嗚優涓殑鑷櫖-鐐庣棁灝忎綋淇″彿閫氳礬銆?/span>(A) 浣跨敤铔嬬櫧璐ㄥ嵃榪瑰垎鏋?ASC銆?/span>Caspase1-p20銆?/span>ULK1銆?/span>ATG16L1 鍜?ER尾 鐨勮〃杈炬按騫熾?/span>(B) ER尾浜岃仛鍖栫殑媯嫻嬨?/span>(C) 緇嗚優涓殑 EGFP-mCherry-LC3B錛堥粍鑹詫級琛ㄨ揪銆?/span>(D)鑷櫖鐩稿叧鏂戠偣闃蟲?/span>緇嗚優瀹氶噺鍒嗘瀽銆?/span>

鍥?/span>4. GEN-NPs 瀵硅偁閬撳井鐢熺墿緹ょ殑璋冭妭浣滅敤銆?/span>(A) 綺究寰敓鐗╃兢緇勬垚鍦ㄥ睘姘村鉤涓婄殑鍙樺寲銆?/span>(B) 涓嶅悓澶勭悊緇勭殑鑲犻亾寰敓鐗╃兢 偽 澶氭牱鎬с?/span>(C) 涓嶅悓澶勭悊緇勪腑寰敓鐗╃兢钀界殑棣欏啘鎸囨暟銆?/span> (D) 浠ｈ〃鎬ф牱鍝佷腑寰敓鐗╃兢緇勬垚鐨?NMDS 鍒嗘瀽銆?/span>


鐩稿叧閾炬帴

https://pubs.acs.org/doi/pdf/10.1021/acsami.1c09215

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