私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

當前位置:群英聚首 > 論文著作 > 正文
The pH-induced thermosensitive poly (NIPAAm-co-AAc-co-HEMA)-g-PCL micelles used as a drug carrier
來源:戴煒楓博士后個人網站 發布日期:2010-11-30
作者:Weifeng Dai, Zhengzhen Du, Yan Zhang, Minliang Ru, Meidong Lang
關鍵字:poly(ε-capro1actone), PNIPAAm-co-PAAc-co-P(HEMA-PCL) graft copolymer, self assembly, core-shell structure,drug delivery
論文來源:期刊
具體來源:Journal of Materials Science: Materials in Medicine 2010, 21, 1881–1890
發表時間:2010年

Themacromonomer of 2-hydroxyethyl methyacrylate-caprolactone (HEMA-PCL) was synthesized by the ring-opening polymerization (ROP) of ε-caprolactone initiated by 2-hydroxyethyl methyacrylate (HEMA). The graft terpolymers of PNIPAAm-co-PAAc-co-P(HEMA-PCL) with varying mole ratios were subsequently synthesizedby free radical polymerization of HEMA-PCL, N-isopropylacrylamide (NIPAAm) and acrylic acid (AAc). The copolymers were characterized by NMRFT-IR and GPC and were self-assembly in the selective solvent. Micellization behaviors of micelles were studied by TEM and DLS. The micelles exhibited a phase transition temperature which can be readily adjusted by controlling the components of copolymer in the preparation process and pH value in the micellization system. Micelle loaded with doxorubicin (DOX) was used to evaluate the drug release behavior. The release of DOX from micelles could be controlled by varying the pH and temperature in buffer solutions. This new prepared PNIPAAM-co-PAAC-co-P(HEMA-PCL) nanoparticles are expected to potentially use as a new anticancerdrug carrier for intracellular delivery.

Copyright © 2005 Polymer.cn All rights reserved
中國聚合物網 版權所有
經營性網站備案信息

京公網安備11010502032929號

工商備案公示信息

京ICP證050801號

京ICP備12003651號

主站蜘蛛池模板: 丹巴县| 楚雄市| 南安市| 黄陵县| 汕尾市| 美姑县| 通化市| 句容市| 平昌县| 宜黄县| 奉节县| 双江| 舞钢市| 淳化县| 阳曲县| 芜湖县| 当阳市| 化德县| 阜新市| 新泰市| 确山县| 遂宁市| 蓬安县| 黄龙县| 陆川县| 定安县| 云阳县| 怀宁县| 娱乐| 综艺| 武宣县| 平武县| 高州市| 蕲春县| 页游| 习水县| 肇州县| 司法| 公安县| 读书| 陇川县|