私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

當(dāng)前位置:群英聚首 > 論文著作 > 正文
Micellar carrier based on methoxy poly(ethylene glycol)-blockpoly( e-caprolactone) block copolymers bearing ketone groups on the polyester block for doxorubicin delivery
來源:戴煒楓博士后個人網(wǎng)站 發(fā)布日期:2010-11-30
作者:Yueying He, Yan Zhang, Chunhua Gu, Weifeng Dai, Meidong Lang
關(guān)鍵字:Methoxy poly(ethylene glycol)-block-poly(ε-caprolactone); Bearing ketone Groups; Micelles carrier; Doxorubicin, Drug release
論文來源:期刊
具體來源:Journal of Materials Science: Materials in Medicine 2010, 21, 567–574
發(fā)表時間:2010年

Block copolymers of Methoxy poly(ethylene glycol)-block-poly(e-caprolactone) bearing ketone groups (MPEG-b-P(CL-co-OPD)) are synthesized and evaluated for its potential to form micelles containing doxorubicin (DOX), a representative anticancer drug, by using an in vitro method based on membrane dialysis to emulate drug release in vivo. The 1H NMR spectra of the prepared block copolymers in D2O solution exhibit peaks due to the P(OPD-co-CL) in decreased intensity, indicates that the polymers form micelle particles containing the hydrophilic segments in their external parts. The CMC of the copolymer decrease with an increase in the content of ketone groups in the hydrophobic chain. Drug-free and drug-loaded solutions of structurally related copolymers indicate the polymeric aggregation into micellar-type constructs. The size of the drug-loaded micelles is found to be larger than corresponding drug-free micelles. The release rate of MPEG-b-PCL micelles is faster than MPEGb-P(OPD-co-CL) micelles in pH 7.4 buffered solution and they have a similar release rate in pH 5.0 buffered solution. This study, therefore, confirms the potential of a novel functional block copolymers, Methoxy poly(ethylene glycol)-block-poly(e-caprolactone) bearing ketone Groups, for the formation of polymeric micelles for drug delivery.

Copyright © 2005 Polymer.cn All rights reserved
中國聚合物網(wǎng) 版權(quán)所有
經(jīng)營性網(wǎng)站備案信息

京公網(wǎng)安備11010502032929號

工商備案公示信息

京ICP證050801號

京ICP備12003651號

主站蜘蛛池模板: 浪卡子县| 哈尔滨市| 泰州市| 屯门区| 合阳县| 临沂市| 奈曼旗| 措勤县| 偏关县| 临沭县| 诸暨市| 辰溪县| 延寿县| 乌鲁木齐市| 大理市| 南安市| 昌乐县| 和顺县| 贵定县| 青海省| 正阳县| 六枝特区| 莱州市| 犍为县| 常州市| 怀宁县| 林周县| 临高县| 鄯善县| 西藏| 鄂托克前旗| 通道| 昭平县| 那坡县| 阿鲁科尔沁旗| 泗洪县| 东乌| 济南市| 柏乡县| 六盘水市| 永川市|