私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

當前位置:群英聚首 > 論文著作 > 正文
Water Promoting Electron Hole Transport between Tyrosine and Cysteine in Proteins via a Special Mechanism: Double Proton Coupled Electron Transfer
來源:陳效華教授個人網站 發布日期:2016-04-04
作者:Xiaohua Chen*, Guangcai Ma, Weichao Sun, Hongjing Dai, Dong Xiao, Yanfang Zhang, Xin Qin, Yongjun Li
關鍵字:Tyrosine; Cysteine; Double Proton Coupled Electron Transfer
論文來源:期刊
具體來源:J. Am. Chem. Soc., 2014, 136 (12), pp 4515–4524
發表時間:2014年
The proton/electron transfer reactions between cysteine residue (Cys) and tyrosinyl radical (Tyr?) are an important step for many enzyme-catalyzed processes. On the basis of the statistical analysis of protein data bank, we designed three representative models to explore the possible proton/electron transfer mechanisms from Cys to Tyr? in proteins. Our ab initio calculations on simplified models and quantum mechanical/molecular mechanical (QM/MM) calculations on real protein environment reveal that the direct electron transfer between Cys and Tyr? is difficult to occur, but an inserted water molecule can greatly promote the proton/electron transfer reactions by a double-proton-coupled electron transfer (dPCET) mechanism. The inserted H2O plays two assistant roles in these reactions. The first one is to bridge the side chains of Tyr? and Cys via two hydrogen bonds, which act as the proton pathway, and the other one is to enhance the electron overlap between the lone-pair orbital of sulfur atom and the π-orbital of phenol moiety and to function as electron transfer pathway. This water-mediated dPCET mechanism may offer great help to understand the detailed electron transfer processes between Tyr and Cys residues in proteins, such as the electron transfer from Cys439 to Tyr730? in the class I ribonucleotide reductase.
Copyright © 2005 Polymer.cn All rights reserved
中國聚合物網 版權所有
經營性網站備案信息

京公網安備11010502032929號

工商備案公示信息

京ICP證050801號

京ICP備12003651號

主站蜘蛛池模板: 西藏| 安阳县| 岑巩县| 大石桥市| 吴江市| 临颍县| 福泉市| 富平县| 文成县| 龙南县| 鞍山市| 清流县| 新乡市| 温州市| 绥滨县| 嘉荫县| 墨江| 阜城县| 黄骅市| 四子王旗| 突泉县| 册亨县| 高要市| 荣昌县| 凤冈县| 惠东县| 新密市| 邓州市| 六安市| 新河县| 宁波市| 商都县| 措美县| 和平县| 太和县| 伊宁市| 花垣县| 高密市| 天气| 巩留县| 石城县|