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Fabrication and Characterization of Nano-HAp Reinforced Poly-D-L-Iactide Scaffolds with Poly (ethylene glycol) /Dexamethasone Coatings  
Fabrication and Characterization of Nano-HAp Reinforced Poly-D-L-Iactide Scaffolds with Poly (ethylene glycol) /Dexamethasone Coatings
資料類型: PDF文件
關鍵詞: pdlla/nano-hap  composites  porous  drug  release  shape  memory  
effect  
資料大?。?/td> 107K
所屬學科: 分子表征
來源: 第六屆亞歐研討會上處理和性能增強聚合物會議文集(2013.6.2-6 武漢)
簡介:
Multifunctionalscaffoldscl],whichhavecontrollablebiodegradability,drugdeliveryfunction,andshapememoryeffect,havebeenattractinggreatresearchinterestinthefieldofbonetissueengineeringrecently.Anoveltechniquecombiningwithpolymercoagulation,coldcompressionmoulding,saltparticulateleachingandadrugcoatingmethodhasbeendevelopedtofabricateporouspoly-D-L-lactide/nano-hydroxyapatite(PDLLA/nano-HAp)scaffoldswithpoly(ethyleneglycol)/dexamethasone(PEG/Dex)coatingsC2].Thescaffoldsfabricatedbythistechniquepossesshomogenousporenetworkswithindependentlycontrollableporosityandporesize.Fillingthematrixwithnano-HApparticlescanimprovethemechanicalpropertiesofthecompositescaffolds.ThesurfacehydrophilicityofthescaffoldwasfoundtobeimprovedbyaPEG/Dexcoatingandnano-HApaddition.AninvitrodrugreleasestudyofthePEG/DexcoatedPDLLA/nano-HApscaffoldshasshownthatthedrugreleasebehaviorofthescaffoldscanbeadjustedbyvaryingtheporositylevelandthefilledvolumefractionofthenano-HAp.Apatitecouldbeformedthecompositescaffoldwithnano-HApafterexposuretoasimulatedbodyfluid,leadingtoanimprovementinthebioactivityandapatiteformationabilityofthescaffold.Shapememorypropertiesofthescaffoldshavebeendemonstratedbyshaperecoveryandcyclicthermalmechanicaltests.Theresultsshowthattheshaperecoveryratioandshapefixityrateofthescaffoldsareinfluencedbytheporosity.Moreover,therecoverabilityofthecompositescaffoldsisalsoaffectedbythecontentofthenano-HAp.
作者: L. Ched , C. Y. Tang, C. P. Tsui, D. Z. Chen
上傳時間: 2013-06-25 13:04:16
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