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Microemulsion Supramolecular Gels for Protein Modulated Hydrophilic/Hydrophobic Dual-drug Delivery

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關(guān)鍵詞：

Microemulsion supramolecular gels Dual-drug delivery Protein modulated

資料大小：

105K

所屬學(xué)科：

分子表征

來源：

第六屆亞歐研討會上處理和性能增強(qiáng)聚合物會議文集（2013.6.2-6 武漢）

簡介：

Mutil-drugdeliverysystemcanimprovetheefficiencyofthetreatmentofdiseases.Inthiswork,amicroemulsionsupramoleculargeI(MSG)wasdevelopedasdualdrugreleasedeliverysystem.Themicroemulsionconsistsofisopropylmyristate,Tween80,propyleneglycolandPBS;andl,3:2,4-di-O-benzylidene-D-sorbitol(DBS)wasusedforgelationthemicroemulsion.5-aminosalicylicacid(5-ASA)andcurcumin(Cur)wereemployedasdual-drugmodelfortheinvestigationofproteinmodulatedreleasebehaviorinthisdeliverysystem.DSCanddyesolubilitytestsshowedthatthepreparedmicroemulsionisbicontinuous;SEMimagesrevealedthatMSGhasathree-dimensionalnetwork.RheologicalmeasurementsrevealedthatMSGexhibitsawell-developednetworkandtheadditionofdualdrugexertsnoeffectonthetheologicalpropertiesofMSG.Theresultsindicatedthatthedualdrugreleasebehaviorcanbemodulatedbybovineserumalbumin(BSA).AtpH7.4,BSArestrainedthereleaseofdualdrug.WhenDBSconcentrationisl.5wt%,atpH7.4,thereleaseratesof5-ASAandCurdecreased14.46%and3%withthepresenceof0.5mg/mLBSArespectively.However,inacidicmedia(pHl.2)andweakacidicmedia(pH5.8andpH6.8),BSAcouldpromotethereleaseratesofdualdrug.AtpH5.8,thereleaseratesof5-ASAandCurincreased17.08%and7.62%withthepresenceofl.0mg/mLBSArespectively.TheseresultsrevealedthatMSGasaquicklyresponsetotheenvironmentstimulationdeliverysystemshaspotentialapplicationinmutil-drugrelease.

作者：

W. Li , Y. J. Yang, H. Wang

上傳時(shí)間：

2013-07-04 14:07:45

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