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Crosslinking of poly(L-lactide) nanofibers with triallyl isocyanutrate by gamma-irradiation

資料類型：

PDF文件

關(guān)鍵詞：

poly (L-lactide) nanofibers crosslinking triallyl isocyanutrate gamma-irradiation

資料大小：

2806K

所屬學(xué)科：

分子表征

來源：

ICAFPM 2011先進(jìn)纖維與聚合物材料國際學(xué)術(shù)會議（2011.8.15~17，上海）

簡介：

Poly(L-lactide)(PLLA)nanofiberhasattractedconsiderableattentionsduetoitspotentialapplicationasatissueengineeringscaffold,butitspoorthermalstabilityandmechanicalpropertiesrestrictitsapplications.Inthiswork,triallyisocyanurate(TAIC)wasaddedintoPLLAsolutionatdifferentratiosandfabricatedintonanofibrousmatsbyelectrospinningtechnique,thematswerethenirradiatedbygammarayatdifferentradiationdosestocrosslinkthePLLAchains.ThethermalpropertiesandbiodegradationpropertiesofdifferentPLLAsampleswereinvestigatedandcompared.Furthermore,theinvitrobiocompatibilitieswerealsoevaluatedbyusingmouseL929fibroblasts.Theresultsindicatedthatthethermalstabilityandtensilemechanicalpropertieswereincreasedaftercrosslinking,andthecrosslinkedsamplesirradiatedat10kGyexhibitedthebestenzymaticdegradation.TheinvitroresultsalsorevealedthatthecrosslinkedPLLA/TAICcompositenanofibersdidnotinducecytotoxiceffectsandsuitableforcellgrowth.Therefore,thecrosslinkedPLLAnanofibersareoneofthepromisingmaterialsforfuturetissueengineeringapplications.

作者：

HE Chuanglong, FENG Wei, CAO Lijun, FAN Lingpeng

上傳時(shí)間：

2011-09-28 14:04:55

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